@article{fdi:010026109,
  title = {{S}afety and immunogenicity of three doses of a {N}eisseria meningitidis {A} + {C} diphtheria conjugate vaccine in infants from {N}iger},
  author = {{C}ampagne, {G}. and {G}arba, {A}. and {F}abre, {P}. and {S}chuchat, {A}. and {R}yall, {R}. and {B}oulanger, {D}. and {B}ybel, {M}. and {C}arlone, {G}. and {B}riantais, {P}. and {I}vanoff, {B}. and {X}erri, {B}. and {C}hippaux, {J}ean-{P}hilippe},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground : {H}igh rates of endemic disease and recurrent epidemics of serogroup {A} and {C} meningococcal meningitis continue to occur in sub-{S}aharan {A}frica. {A} meningococcal {A}+ + {C} polysaccharide diptheria-toxoid-conjugated vaccine may address this issue. {M}ethods : {I}n {N}iger three doses of a bivalent meningococcal {A} + {C} diphtheria-toxoid-conjugated vaccine ({M}en{D}), containing 1, 4 or 16 micrometer grams of each polysaccharide per dose, administered at 6, 10 and 14 weeks of age, were compared with #{H}aemophilus influenzae$ type b-tetanus toxoid-conjugated ({PRP}-{T}) vaccine given with the same schedule or with a meningococcal {A} + {C} polysacharide vaccine ({M}en{PS}) given at 10 and 14 weeks of age. {O}ne blood sample was taken at the time of enrollment (6 weeks of age) and another was taken 4 weeks after the primary series. {R}esults : all doses of {M}en{D} were well-tolerated. {A}fter the primary series a higher proportion of infants had detectable serum bactericidal activity against serogroup {A} for each dose of {M}en{D} (from 94% to 100%) than for {M}en{PS} (31%) or #{H}. influenzae$ type b-tetanus toxoid-conjuugated vaccine (18.9%) ; {P} is less than or equal to 0.05. {S}ignificant differences were also observed for serogroup {C} {M}en{D} 4 micrometer grams or {M}en{D} 16 micrometer grams (100%) vs. {M}en{PS} (69.7%) or #{H}aemophilus influenzae$ type b-tetanus toxoid-conjugated vaccine (24.3%) ; {P} is less than or equal to 0.05. {W}hen {M}en{PS} vaccine was given to 11-month children, the immune response measured by both enzyme-linked immunosorbent assay and serum bactericidal assay was greater in those previously immunized with {M}en{D} than in those immunized with {M}en{PS} vaccine. {C}onclusion : {M}en{D} was safe among infants in {N}iger, and immunization led to significantly greater functional antibody activity than with {M}en{PS}. {T}he 4-micrometer gram dose of {M}ed{D} for both the {A} and {C} serogroups has been selected for further studies. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{EPIDEMIE} ; {ENFANT} {D}'{AGE} {PRESCOLAIRE} ; {VACCINATION} ; {DOSE} ; {TOXICITE} ; {IMMUNITE} ; {METHODE} {D}'{ANALYSE} ; {TEST} {ELISA} ; {TEST} {BIOLOGIQUE} ; {ETUDE} {EXPERIMENTALE} ; {ETUDE} {COMPARATIVE} ; {MENINGITE} ; {MEND} ; {MENPS} ; {PRP} {T} ; {NIGER} ; {NIAMEY}},
  booktitle = {},
  journal = {{P}ediatric {I}nfectious {D}isease {J}ournal},
  volume = {19},
  numero = {},
  pages = {144--150},
  ISSN = {0891-3668},
  year = {2000},
  URL = {https://www.documentation.ird.fr/hor/fdi:010026109},
}