Horizon 1 1 17 ACLN : Articles dans des revues avec comité de lecture non répertoriées par l'AERES Pediatric Infectious Disease Journal 144-150 EPIDEMIE ENFANT D'AGE PRESCOLAIRE VACCINATION DOSE TOXICITE IMMUNITE METHODE D'ANALYSE TEST ELISA TEST BIOLOGIQUE ETUDE EXPERIMENTALE ETUDE COMPARATIVE MENINGITE MEND MENPS PRP T NIGER NIAMEY 2000 fdi:010026109 ENG Pediatric Infectious Disease Journal 0891-3668 https://www.documentation.ird.fr/hor/fdi:010026109 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_7/b_fdi_59-60/010026109.pdf 19 Horizon (IRD) Background : High rates of endemic disease and recurrent epidemics of serogroup A and C meningococcal meningitis continue to occur in sub-Saharan Africa. A meningococcal A+ + C polysaccharide diptheria-toxoid-conjugated vaccine may address this issue. Methods : In Niger three doses of a bivalent meningococcal A + C diphtheria-toxoid-conjugated vaccine (MenD), containing 1, 4 or 16 micrometer grams of each polysaccharide per dose, administered at 6, 10 and 14 weeks of age, were compared with #Haemophilus influenzae$ type b-tetanus toxoid-conjugated (PRP-T) vaccine given with the same schedule or with a meningococcal A + C polysacharide vaccine (MenPS) given at 10 and 14 weeks of age. One blood sample was taken at the time of enrollment (6 weeks of age) and another was taken 4 weeks after the primary series. Results : all doses of MenD were well-tolerated. After the primary series a higher proportion of infants had detectable serum bactericidal activity against serogroup A for each dose of MenD (from 94% to 100%) than for MenPS (31%) or #H. influenzae$ type b-tetanus toxoid-conjuugated vaccine (18.9%) ; P is less than or equal to 0.05. Significant differences were also observed for serogroup C MenD 4 micrometer grams or MenD 16 micrometer grams (100%) vs. MenPS (69.7%) or #Haemophilus influenzae$ type b-tetanus toxoid-conjugated vaccine (24.3%) ; P is less than or equal to 0.05. When MenPS vaccine was given to 11-month children, the immune response measured by both enzyme-linked immunosorbent assay and serum bactericidal assay was greater in those previously immunized with MenD than in those immunized with MenPS vaccine. Conclusion : MenD was safe among infants in Niger, and immunization led to significantly greater functional antibody activity than with MenPS. The 4-micrometer gram dose of MedD for both the A and C serogroups has been selected for further studies. (Résumé d'auteur) 052MALTRA05