Campagne G. auteur aut IRD Garba A. auteur aut IRD Fabre P. auteur aut IRD Schuchat A. auteur aut IRD Ryall R. auteur aut IRD Boulanger D. auteur aut IRD Bybel M. auteur aut IRD Carlone G. auteur aut IRD Briantais P. auteur aut IRD Ivanoff B. auteur aut IRD Xerri B. auteur aut IRD Chippaux Jean-Philippe auteur aut IRD text journalArticle eng text/pdf reformatted digital access Background : High rates of endemic disease and recurrent epidemics of serogroup A and C meningococcal meningitis continue to occur in sub-Saharan Africa. A meningococcal A+ + C polysaccharide diptheria-toxoid-conjugated vaccine may address this issue. Methods : In Niger three doses of a bivalent meningococcal A + C diphtheria-toxoid-conjugated vaccine (MenD), containing 1, 4 or 16 micrometer grams of each polysaccharide per dose, administered at 6, 10 and 14 weeks of age, were compared with Haemophilus influenzae type b-tetanus toxoid-conjugated (PRP-T) vaccine given with the same schedule or with a meningococcal A + C polysacharide vaccine (MenPS) given at 10 and 14 weeks of age. One blood sample was taken at the time of enrollment (6 weeks of age) and another was taken 4 weeks after the primary series. Results : all doses of MenD were well-tolerated. After the primary series a higher proportion of infants had detectable serum bactericidal activity against serogroup A for each dose of MenD (from 94% to 100%) than for MenPS (31%) or H. influenzae type b-tetanus toxoid-conjuugated vaccine (18.9%) ; P is less than or equal to 0.05. Significant differences were also observed for serogroup C MenD 4 micrometer grams or MenD 16 micrometer grams (100%) vs. MenPS (69.7%) or Haemophilus influenzae type b-tetanus toxoid-conjugated vaccine (24.3%) ; P is less than or equal to 0.05. When MenPS vaccine was given to 11-month children, the immune response measured by both enzyme-linked immunosorbent assay and serum bactericidal assay was greater in those previously immunized with MenD than in those immunized with MenPS vaccine. Conclusion : MenD was safe among infants in Niger, and immunization led to significantly greater functional antibody activity than with MenPS. The 4-micrometer gram dose of MedD for both the A and C serogroups has been selected for further studies. (Résumé d'auteur) specialized EPIDEMIE ENFANT D'AGE PRESCOLAIRE VACCINATION DOSE TOXICITE IMMUNITE METHODE D'ANALYSE TEST ELISA TEST BIOLOGIQUE ETUDE EXPERIMENTALE ETUDE COMPARATIVE MENINGITE MEND MENPS PRP T NIGER NIAMEY 052MALTRA05 19 144-150 2000 0891-3668 https://www.documentation.ird.fr/hor/fdi:010026109 0891-3668 [F B010026109] https://www.documentation.ird.fr/hor/fdi:010026109 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_7/b_fdi_59-60/010026109.pdf IRD - Base Horizon / Pleins textes 2001-08-21 2018-08-17 fdi:010026109 fre