Fievet Nadine, Moussa M., Tami G., Maubert B., Cot Michel, Deloron P., Chaouat G. (2001). Plasmodium falciparum induces a Th1/Th2 disequilibrium, favoring the Th1-type pathway, in the human placenta. Journal of Infectious Diseases, 183 (10), p. 1530-1534. ISSN 0002-1899.
Titre du document
Plasmodium falciparum induces a Th1/Th2 disequilibrium, favoring the Th1-type pathway, in the human placenta
Année de publication
2001
Auteurs
Fievet Nadine, Moussa M., Tami G., Maubert B., Cot Michel, Deloron P., Chaouat G.
Source
Journal of Infectious Diseases, 2001,
183 (10), p. 1530-1534 ISSN 0002-1899
During pregnancy, a local and systemic Th2 bias of maternal immunity favors Th1-dependent infections such as malaria. This study measured cytokines secreted in cultures of chorionic villi, placental blood cells (PBC), and serum in term placentas from 88 malaria-infected and -noninfected Cameroon women. Interleukin (IL)-2 and-4 were consistently low ; IL-1Beta, IL-6, granulocyte-macrophage colony-stimulating factor, and transforming growth factor (TGF)-Beta2 were highest in PBC cultures. Malaria placental infection increased Th1-type cytokines, whereas Th-type cytokines and TGF-Beta2 were unchanged. Addition of lipopolysaccharide or infected erythrocytes to cultures increased TNF-alpha, IL-1Beta, IL-6,and IL-10 secretions but not those of IFN-gamma and IL-4. Overall, Plasmodium falciparum induced a placental immune response involving both Th1- and Th2-type cell activation. Although the Th1 pathway was favored, IL-10 secretion was also increased, and this increase should be effective in protecting the placenta by controlling the negative effects of Th1 cytokines on pregnancy. (Résumé d'auteur)
Plan de classement
Epidémiologie du paludisme [052ANOPAL03]
Descripteurs
PALUDISME ; AGENT PATHOGENE ; FEMME ; GROSSESSE ; IMMUNITE ; IMMUNOLOGIE ; CELLULE ; CULTURE IN VITRO ; ETUDE EXPERIMENTALE ; TRANSMISSION PLACENTAIRE ; TH1 CYTOKINE ; TH2 CYTOKINE
Description Géographique
CAMEROUN ; YAOUNDE
Localisation
Fonds IRD [F B010025993] ;
Montpellier (Centre IRD)
Identifiant IRD
fdi:010025993
