Fievet Nadine auteur aut IRD Moussa M. auteur aut IRD Tami G. auteur aut IRD Maubert B. auteur aut IRD Cot Michel auteur aut IRD Deloron P. auteur aut IRD Chaouat G. auteur aut IRD text journalArticle eng text/pdf reformatted digital access During pregnancy, a local and systemic Th2 bias of maternal immunity favors Th1-dependent infections such as malaria. This study measured cytokines secreted in cultures of chorionic villi, placental blood cells (PBC), and serum in term placentas from 88 malaria-infected and -noninfected Cameroon women. Interleukin (IL)-2 and-4 were consistently low ; IL-1Beta, IL-6, granulocyte-macrophage colony-stimulating factor, and transforming growth factor (TGF)-Beta2 were highest in PBC cultures. Malaria placental infection increased Th1-type cytokines, whereas Th-type cytokines and TGF-Beta2 were unchanged. Addition of lipopolysaccharide or infected erythrocytes to cultures increased TNF-alpha, IL-1Beta, IL-6,and IL-10 secretions but not those of IFN-gamma and IL-4. Overall, Plasmodium falciparum induced a placental immune response involving both Th1- and Th2-type cell activation. Although the Th1 pathway was favored, IL-10 secretion was also increased, and this increase should be effective in protecting the placenta by controlling the negative effects of Th1 cytokines on pregnancy. (Résumé d'auteur) specialized PALUDISME AGENT PATHOGENE FEMME GROSSESSE IMMUNITE IMMUNOLOGIE CELLULE CULTURE IN VITRO ETUDE EXPERIMENTALE TRANSMISSION PLACENTAIRE TH1 CYTOKINE TH2 CYTOKINE CAMEROUN YAOUNDE 052ANOPAL03 183 10 1530-1534 2001 0002-1899 https://www.documentation.ird.fr/hor/fdi:010025993 10.1086/320201 0002-1899 [F B010025993] https://www.documentation.ird.fr/hor/fdi:010025993 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_7/b_fdi_59-60/010025993.pdf IRD - Base Horizon / Pleins textes 2001-08-21 2018-08-17 fdi:010025993 fre