%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Fievet, Nadine
%A Moussa, M.
%A Tami, G.
%A Maubert, B.
%A Cot, Michel
%A Deloron, P.
%A Chaouat, G.
%T Plasmodium falciparum induces a Th1/Th2 disequilibrium, favoring the Th1-type pathway, in the human placenta
%D 2001
%L fdi:010025993
%G ENG
%J Journal of Infectious Diseases
%@ 0002-1899
%K PALUDISME ; AGENT PATHOGENE ; FEMME ; GROSSESSE ; IMMUNITE ; IMMUNOLOGIE ; CELLULE ; CULTURE IN VITRO ; ETUDE EXPERIMENTALE
%K TRANSMISSION PLACENTAIRE ; TH1 CYTOKINE ; TH2 CYTOKINE
%K CAMEROUN ; YAOUNDE
%K NKOLDONGO ; DJOUNGOLO
%N 10
%P 1530-1534
%R 10.1086/320201
%U https://www.documentation.ird.fr/hor/fdi:010025993
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_7/b_fdi_59-60/010025993.pdf
%V 183
%W Horizon (IRD)
%X During pregnancy, a local and systemic Th2 bias of maternal immunity favors Th1-dependent infections such as malaria. This study measured cytokines secreted in cultures of chorionic villi, placental blood cells (PBC), and serum in term placentas from 88 malaria-infected and -noninfected Cameroon women. Interleukin (IL)-2 and-4 were consistently low ; IL-1Beta, IL-6, granulocyte-macrophage colony-stimulating factor, and transforming growth factor (TGF)-Beta2 were highest in PBC cultures. Malaria placental infection increased Th1-type cytokines, whereas Th-type cytokines and TGF-Beta2 were unchanged. Addition of lipopolysaccharide or infected erythrocytes to cultures increased TNF-alpha, IL-1Beta, IL-6,and IL-10 secretions but not those of IFN-gamma and IL-4. Overall, #Plasmodium falciparum$ induced a placental immune response involving both Th1- and Th2-type cell activation. Although the Th1 pathway was favored, IL-10 secretion was also increased, and this increase should be effective in protecting the placenta by controlling the negative effects of Th1 cytokines on pregnancy. (Résumé d'auteur)
%$ 052ANOPAL03