@article{fdi:010025993,
  title = {{P}lasmodium falciparum induces a {T}h1/{T}h2 disequilibrium, favoring the {T}h1-type pathway, in the human placenta},
  author = {{F}ievet, {N}adine and {M}oussa, {M}. and {T}ami, {G}. and {M}aubert, {B}. and {C}ot, {M}ichel and {D}eloron, {P}. and {C}haouat, {G}.},
  editor = {},
  language = {{ENG}},
  abstract = {{D}uring pregnancy, a local and systemic {T}h2 bias of maternal immunity favors {T}h1-dependent infections such as malaria. {T}his study measured cytokines secreted in cultures of chorionic villi, placental blood cells ({PBC}), and serum in term placentas from 88 malaria-infected and -noninfected {C}ameroon women. {I}nterleukin ({IL})-2 and-4 were consistently low ; {IL}-1{B}eta, {IL}-6, granulocyte-macrophage colony-stimulating factor, and transforming growth factor ({TGF})-{B}eta2 were highest in {PBC} cultures. {M}alaria placental infection increased {T}h1-type cytokines, whereas {T}h-type cytokines and {TGF}-{B}eta2 were unchanged. {A}ddition of lipopolysaccharide or infected erythrocytes to cultures increased {TNF}-alpha, {IL}-1{B}eta, {IL}-6,and {IL}-10 secretions but not those of {IFN}-gamma and {IL}-4. {O}verall, #{P}lasmodium falciparum$ induced a placental immune response involving both {T}h1- and {T}h2-type cell activation. {A}lthough the {T}h1 pathway was favored, {IL}-10 secretion was also increased, and this increase should be effective in protecting the placenta by controlling the negative effects of {T}h1 cytokines on pregnancy. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{PALUDISME} ; {AGENT} {PATHOGENE} ; {FEMME} ; {GROSSESSE} ; {IMMUNITE} ; {IMMUNOLOGIE} ; {CELLULE} ; {CULTURE} {IN} {VITRO} ; {ETUDE} {EXPERIMENTALE} ; {TRANSMISSION} {PLACENTAIRE} ; {TH}1 {CYTOKINE} ; {TH}2 {CYTOKINE} ; {CAMEROUN} ; {YAOUNDE} ; {NKOLDONGO} ; {DJOUNGOLO}},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {183},
  numero = {10},
  pages = {1530--1534},
  ISSN = {0002-1899},
  year = {2001},
  DOI = {10.1086/320201},
  URL = {https://www.documentation.ird.fr/hor/fdi:010025993},
}