Inchausti A., Yaluff G., Rojas de Arias A., Torres S., Ferreira M.E., Nakayama H., Schinini A., Lorenzen K., Anke T., Fournet Alain. (1997). Leishmanicidal and trypanocidal activity of extracts and secondary metabolites from basidiomycetes. Phytotherapy Research, 11, p. 193-197. ISSN 0951-418X.
Titre du document
Leishmanicidal and trypanocidal activity of extracts and secondary metabolites from basidiomycetes
Année de publication
1997
Auteurs
Inchausti A., Yaluff G., Rojas de Arias A., Torres S., Ferreira M.E., Nakayama H., Schinini A., Lorenzen K., Anke T., Fournet Alain
Source
Phytotherapy Research, 1997,
11, p. 193-197 ISSN 0951-418X
Seventeen extracts and seven secondary metabolites isolated from basidiomycetes were tested in medium culture against promastigote forms of Leishmania spp. and bloodstream forms of Trypanosoma cruzi. Extracts from the culture filtrate or mycelium were generally inactive against the parasites except the Zucoagaricus genus mycelium extract which reduced by 47% the number of bloodstream forms. Striatin A, striatin B and podoscyphic acid exhibited in vitro activity at 10,5 and 100 micrograms/mL, respectively. One compound showed activity against bloodstream forms of T. cruzi, the sesquiterpenoid naematolin, lysing the parasites by 79%. BALB/c mice infected with L. amazonensis were treated three weeks post-infection with striatin A and striatin B by subcutaneous route for 15 days at 10 mg/kg daily. The reference drug, N-methylglucamine antimonate, administered by subcutaneous injections at 28 mg Sbv/kg/day for 15 days reduced the parasite burden by 71,2% (p<0,05). Subcutaneous administration of striatin A at 10 mg/kg produced a weak decrease of the parasite burdens in the footpad by 17,6%. The treatment with striatin B had no effect and showed higher toxicity than striatin A. (Résumé d'auteur)
Plan de classement
Lutte [052GLOTRY03]
;
Lutte [052PHLEIS03]
;
Substances naturelles : utilisation pharmacologique [076PLAMED03]
Descripteurs
LEISHMANIOSE ; TRYPANOSOMIASE HUMAINE ; TRAITEMENT MEDICAL ; EFFICACITE ; ANIMAL DE LABORATOIRE ; CHAMPIGNON ; EXTRACTION ; ETUDE EXPERIMENTALE ; ETUDE COMPARATIVE ; SESQUITERPENE ; DITERPENE
Description Géographique
PARAGUAY
Localisation
Fonds IRD [F B010010459] ;
La Paz
;
Montpellier (Centre IRD)
Identifiant IRD
fdi:010010459
