Leishmanicidal and trypanocidal activity of extracts and secondary metabolites from basidiomycetes Inchausti, A. Yaluff, G. Rojas de Arias, A. Torres, S. Ferreira, M.E. Nakayama, H. Schinini, A. Lorenzen, K. Anke, T. /Fournet, Alain LEISHMANIOSE TRYPANOSOMIASE HUMAINE TRAITEMENT MEDICAL EFFICACITE ANIMAL DE LABORATOIRE CHAMPIGNON EXTRACTION ETUDE EXPERIMENTALE ETUDE COMPARATIVE SESQUITERPENE DITERPENE Seventeen extracts and seven secondary metabolites isolated from basidiomycetes were tested in medium culture against promastigote forms of Leishmania spp. and bloodstream forms of Trypanosoma cruzi. Extracts from the culture filtrate or mycelium were generally inactive against the parasites except the Zucoagaricus genus mycelium extract which reduced by 47% the number of bloodstream forms. Striatin A, striatin B and podoscyphic acid exhibited in vitro activity at 10,5 and 100 micrograms/mL, respectively. One compound showed activity against bloodstream forms of T. cruzi, the sesquiterpenoid naematolin, lysing the parasites by 79%. BALB/c mice infected with L. amazonensis were treated three weeks post-infection with striatin A and striatin B by subcutaneous route for 15 days at 10 mg/kg daily. The reference drug, N-methylglucamine antimonate, administered by subcutaneous injections at 28 mg Sbv/kg/day for 15 days reduced the parasite burden by 71,2% (p<0,05). Subcutaneous administration of striatin A at 10 mg/kg produced a weak decrease of the parasite burdens in the footpad by 17,6%. The treatment with striatin B had no effect and showed higher toxicity than striatin A. (Résumé d'auteur) 1997 text https://www.documentation.ird.fr/hor/fdi:010010459 fdi:010010459 Inchausti A., Yaluff G., Rojas de Arias A., Torres S., Ferreira M.E., Nakayama H., Schinini A., Lorenzen K., Anke T., Fournet Alain. Leishmanicidal and trypanocidal activity of extracts and secondary metabolites from basidiomycetes. 1997, 11, 193-197 EN PARAGUAY