%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Inchausti, A.
%A Yaluff, G.
%A Rojas de Arias, A.
%A Torres, S.
%A Ferreira, M.E.
%A Nakayama, H.
%A Schinini, A.
%A Lorenzen, K.
%A Anke, T.
%A Fournet, Alain
%T Leishmanicidal and trypanocidal activity of extracts and secondary metabolites from basidiomycetes
%D 1997
%L fdi:010010459
%G ENG
%J Phytotherapy Research
%@ 0951-418X
%K LEISHMANIOSE ; TRYPANOSOMIASE HUMAINE ; TRAITEMENT MEDICAL ; EFFICACITE ; ANIMAL DE LABORATOIRE ; CHAMPIGNON ; EXTRACTION ; ETUDE EXPERIMENTALE ; ETUDE COMPARATIVE
%K SESQUITERPENE ; DITERPENE
%K PARAGUAY
%P 193-197
%R 10.1002/(SICI)1099-1573(199705)11:3<193::AID-PTR68>3.0.CO;2-R
%U https://www.documentation.ird.fr/hor/fdi:010010459
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_6/b_fdi_47-48/010010459.pdf
%V 11
%W Horizon (IRD)
%X Seventeen extracts and seven secondary metabolites isolated from basidiomycetes were tested in medium culture against promastigote forms of #Leishmania$ spp. and bloodstream forms of #Trypanosoma cruzi$. Extracts from the culture filtrate or mycelium were generally inactive against the parasites except the #Zucoagaricus$ genus mycelium extract which reduced by 47% the number of bloodstream forms. Striatin A, striatin B and podoscyphic acid exhibited in vitro activity at 10,5 and 100 micrograms/mL, respectively. One compound showed activity against bloodstream forms of #T. cruzi$, the sesquiterpenoid naematolin, lysing the parasites by 79%. BALB/c mice infected with #L. amazonensis$ were treated three weeks post-infection with striatin A and striatin B by subcutaneous route for 15 days at 10 mg/kg daily. The reference drug, N-methylglucamine antimonate, administered by subcutaneous injections at 28 mg Sbv/kg/day for 15 days reduced the parasite burden by 71,2% (p<0,05). Subcutaneous administration of striatin A at 10 mg/kg produced a weak decrease of the parasite burdens in the footpad by 17,6%. The treatment with striatin B had no effect and showed higher toxicity than striatin A. (Résumé d'auteur)
%$ 052PHLEIS03 ; 052GLOTRY03 ; 076PLAMED03