@article{fdi:010010459,
  title = {{L}eishmanicidal and trypanocidal activity of extracts and secondary metabolites from basidiomycetes},
  author = {{I}nchausti, {A}. and {Y}aluff, {G}. and {R}ojas de {A}rias, {A}. and {T}orres, {S}. and {F}erreira, {M}.{E}. and {N}akayama, {H}. and {S}chinini, {A}. and {L}orenzen, {K}. and {A}nke, {T}. and {F}ournet, {A}lain},
  editor = {},
  language = {{ENG}},
  abstract = {{S}eventeen extracts and seven secondary metabolites isolated from basidiomycetes were tested in medium culture against promastigote forms of #{L}eishmania$ spp. and bloodstream forms of #{T}rypanosoma cruzi$. {E}xtracts from the culture filtrate or mycelium were generally inactive against the parasites except the #{Z}ucoagaricus$ genus mycelium extract which reduced by 47% the number of bloodstream forms. {S}triatin {A}, striatin {B} and podoscyphic acid exhibited in vitro activity at 10,5 and 100 micrograms/m{L}, respectively. {O}ne compound showed activity against bloodstream forms of #{T}. cruzi$, the sesquiterpenoid naematolin, lysing the parasites by 79%. {BALB}/c mice infected with #{L}. amazonensis$ were treated three weeks post-infection with striatin {A} and striatin {B} by subcutaneous route for 15 days at 10 mg/kg daily. {T}he reference drug, {N}-methylglucamine antimonate, administered by subcutaneous injections at 28 mg {S}bv/kg/day for 15 days reduced the parasite burden by 71,2% (p<0,05). {S}ubcutaneous administration of striatin {A} at 10 mg/kg produced a weak decrease of the parasite burdens in the footpad by 17,6%. {T}he treatment with striatin {B} had no effect and showed higher toxicity than striatin {A}. ({R}{\'e}sum{\'e} d'auteur)},
  keywords = {{LEISHMANIOSE} ; {TRYPANOSOMIASE} {HUMAINE} ; {TRAITEMENT} {MEDICAL} ; {EFFICACITE} ; {ANIMAL} {DE} {LABORATOIRE} ; {CHAMPIGNON} ; {EXTRACTION} ; {ETUDE} {EXPERIMENTALE} ; {ETUDE} {COMPARATIVE} ; {SESQUITERPENE} ; {DITERPENE} ; {PARAGUAY}},
  booktitle = {},
  journal = {{P}hytotherapy {R}esearch},
  volume = {11},
  numero = {},
  pages = {193--197},
  ISSN = {0951-418{X}},
  year = {1997},
  DOI = {10.1002/({SICI})1099-1573(199705)11:3<193::{AID}-{PTR}68>3.0.{CO};2-{R}},
  URL = {https://www.documentation.ird.fr/hor/fdi:010010459},
}