Thomas A. W., Narum D., Waters A. P., Trape Jean-François, Rogier C., Gonçalves A., Rosario V., Druilhe P., Mitchell G. H., Dennis D. (1994). Aspects of immunity for the AMA-1 family of molecules in humans and non-human primates malarias. In :
Herrera S. (ed.), Jepsen S. (ed.). CEC malaria contract holders meeting. CEC latin american malaria conference. Memorias do Instituto Oswaldo Cruz. Rio de Janeiro, 89 (suppl. 2), 67-70. CEC Malaria Contract Holders Meeting. CEC Latin American Malaria Conference, Cali (COL), 1993/09/05-11. ISSN 0074-0276.
Titre du document
Aspects of immunity for the AMA-1 family of molecules in humans and non-human primates malarias
Année de publication
1994
Auteurs
Thomas A. W., Narum D., Waters A. P., Trape Jean-François, Rogier C., Gonçalves A., Rosario V., Druilhe P., Mitchell G. H., Dennis D.
In
Herrera S. (ed.), Jepsen S. (ed.), CEC malaria contract holders meeting. CEC latin american malaria conference
Source
Memorias do Instituto Oswaldo Cruz. Rio de Janeiro, 1994,
89 (suppl. 2), 67-70 ISSN 0074-0276
Colloque
CEC Malaria Contract Holders Meeting. CEC Latin American Malaria Conference, Cali (COL), 1993/09/05-11
The apical membrane antigen (AMA-1) family of malaria merozoite proteins is characterised by a high degree of inter-species conservation. Evidence that the protein (PK66/AMA-1) from the simian parasite Plasmodium knowlesi was protective in rhesus monkeys suggested that the 83kDa P. falciparum equivalent (PF83/AMA-1) should be investigated for protective effects in humans. Here we briefly review pertinent comparative data, and describe the use of an eukaryotic full length recombinant PF83/AMA-1 molecule to develop a sensitive ELISA for the determination of serological responses in endemic populations. The assay has revealed surprisingly high levels of humoral response to this quantitatively minor antigen. We also show that PK66/AMA-1 inhibitory mAb's are active against merozoites subsequent to release from schizont-infected red cells, further implicating AMA-1 molecules in red cell invasion.
Plan de classement
Lutte [052ANOPAL04]
Descripteurs
PALUDISME ; AGENT PATHOGENE ; PARASITE ; ANTIGENE ; PROTEINE ; IMMUNITE ; SEROLOGIE ; VACCINATION ; ELISA
Localisation
Fonds IRD [F B43280]
Identifiant IRD
fdi:43280
