Thomas A. W. auteur aut IRD Narum D. auteur aut IRD Waters A. P. auteur aut IRD Trape Jean-François auteur aut IRD Rogier C. auteur aut IRD Gonçalves A. auteur aut IRD Rosario V. auteur aut IRD Druilhe P. auteur aut IRD Mitchell G. H. auteur aut IRD Dennis D. auteur aut IRD text journalArticle eng text/pdf reformatted digital access The apical membrane antigen (AMA-1) family of malaria merozoite proteins is characterised by a high degree of inter-species conservation. Evidence that the protein (PK66/AMA-1) from the simian parasite Plasmodium knowlesi was protective in rhesus monkeys suggested that the 83kDa P. falciparum equivalent (PF83/AMA-1) should be investigated for protective effects in humans. Here we briefly review pertinent comparative data, and describe the use of an eukaryotic full length recombinant PF83/AMA-1 molecule to develop a sensitive ELISA for the determination of serological responses in endemic populations. The assay has revealed surprisingly high levels of humoral response to this quantitatively minor antigen. We also show that PK66/AMA-1 inhibitory mAb's are active against merozoites subsequent to release from schizont-infected red cells, further implicating AMA-1 molecules in red cell invasion. specialized PALUDISME AGENT PATHOGENE PARASITE ANTIGENE PROTEINE IMMUNITE SEROLOGIE VACCINATION ELISA 052ANOPAL04 Herrera S. ed. edt IRD Jepsen S. ed. edt IRD 89 suppl. 2 67-70 1994 0074-0276 CEC Malaria Contract Holders Meeting. CEC Latin American Malaria Conference, Cali (COL), 1993/09/05-11 https://www.documentation.ird.fr/hor/fdi:43280 10.1590/S0074-02761994000600016 0074-0276 [F B43280] https://www.documentation.ird.fr/hor/fdi:43280 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_6/b_fdi_39-40/43280.pdf IRD - Base Horizon / Pleins textes 1996-02-19 2025-05-22 fdi:43280 fre