@article{fdi:43280,
  title = {{A}spects of immunity for the {AMA}-1 family of molecules in humans and non-human primates malarias},
  author = {{T}homas, {A}. {W}. and {N}arum, {D}. and {W}aters, {A}. {P}. and {T}rape, {J}ean-{F}ran{\c{c}}ois and {R}ogier, {C}. and {G}on{\c{c}}alves, {A}. and {R}osario, {V}. and {D}ruilhe, {P}. and {M}itchell, {G}. {H}. and {D}ennis, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he apical membrane antigen ({AMA}-1) family of malaria merozoite proteins is characterised by a high degree of inter-species conservation. {E}vidence that the protein ({PK}66/{AMA}-1) from the simian parasite {P}lasmodium knowlesi was protective in rhesus monkeys suggested that the 83k{D}a {P}. falciparum equivalent ({PF}83/{AMA}-1) should be investigated for protective effects in humans. {H}ere we briefly review pertinent comparative data, and describe the use of an eukaryotic full length recombinant {PF}83/{AMA}-1 molecule to develop a sensitive {ELISA} for the determination of serological responses in endemic populations. {T}he assay has revealed surprisingly high levels of humoral response to this quantitatively minor antigen. {W}e also show that {PK}66/{AMA}-1 inhibitory m{A}b's are active against merozoites subsequent to release from schizont-infected red cells, further implicating {AMA}-1 molecules in red cell invasion.},
  keywords = {{PALUDISME} ; {AGENT} {PATHOGENE} ; {PARASITE} ; {ANTIGENE} ; {PROTEINE} ; {IMMUNITE} ; {SEROLOGIE} ; {VACCINATION} ; {ELISA}},
  booktitle = {{CEC} malaria contract holders meeting. {CEC} latin american malaria conference},
  journal = {{M}emorias do {I}nstituto {O}swaldo {C}ruz. {R}io de {J}aneiro},
  volume = {89},
  numero = {suppl. 2},
  pages = {67--70},
  ISSN = {0074-0276},
  year = {1994},
  DOI = {10.1590/{S}0074-02761994000600016},
  URL = {https://www.documentation.ird.fr/hor/fdi:43280},
}