Trape Jean-François, Fribourg-Blanc A., Bosseno Marie-France, Lallemant Marc, Engler R., Mouchet Jean. (1985). Malaria, cause of ahaptoglobinaemia in Africans. Transactions of the Royal Society of Tropical Medicine and Hygiene, 79, 430-434. ISSN 0035-9203.
Titre du document
Malaria, cause of ahaptoglobinaemia in Africans
Année de publication
1985
Type de document
Article
Auteurs
Trape Jean-François, Fribourg-Blanc A., Bosseno Marie-France, Lallemant Marc, Engler R., Mouchet Jean
Source
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1985,
79, 430-434 ISSN 0035-9203
The lack of serum haptoglobin in Africans has been investigated in the Congo, Central Africa, where HpO prevalence is about 30%. This study shows that it is possible to suppress ahaptoglobinaemia within a few weeks by antimalarial chemoprophylaxis, that it does not occur in protected individuals, that ahaptoglobinaemia reappears at its original incidence levels after interruption of chemoprophylaxis, and that some individuals are more susceptible in relation to Hp2 gene. Malaria is the only significant cause of ahaptoglobinaemia in subjects both with and without detectable parasitaemia. The possible mechanisms involved are discussed.
