Trape Jean-François auteur aut IRD Fribourg-Blanc A. auteur aut IRD Bosseno Marie-France auteur aut IRD Lallemant Marc auteur aut IRD Engler R. auteur aut IRD Mouchet Jean auteur aut IRD text journalArticle eng text/pdf reformatted digital access The lack of serum haptoglobin in Africans has been investigated in the Congo, Central Africa, where HpO prevalence is about 30%. This study shows that it is possible to suppress ahaptoglobinaemia within a few weeks by antimalarial chemoprophylaxis, that it does not occur in protected individuals, that ahaptoglobinaemia reappears at its original incidence levels after interruption of chemoprophylaxis, and that some individuals are more susceptible in relation to Hp2 gene. Malaria is the only significant cause of ahaptoglobinaemia in subjects both with and without detectable parasitaemia. The possible mechanisms involved are discussed. specialized ENFANT D'AGE SCOLAIRE PALUDISME CHIMIOPROPHYLAXIE MALADIES ASSOCIEES AHAPTOGLOBINEMIE AMODIAQUINE MEFLOQUINE CONGO 052ANOPAL03 79 430-434 1985 0035-9203 https://www.documentation.ird.fr/hor/fdi:24433 10.1016/0035-9203(85)90053-7 0035-9203 [F B24433] https://www.documentation.ird.fr/hor/fdi:24433 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/pleins_textes_5/b_fdi_18-19/24433.pdf IRD - Base Horizon / Pleins textes 1999-09-06 2025-05-22 fdi:24433 fre