Vanderlinde T., Uno F., Goldstein G., Sabot François, Carareto C. M. A., Vieira C., Markow T. A., Carvalho A. B. (2025). Male sterility in Drosophila mojavensis x D. arizonae hybrids is not caused by gene movements in the Y chromosome. Evolution, Early access, p. [13 p.]. ISSN 0014-3820.
Titre du document
Male sterility in Drosophila mojavensis x D. arizonae hybrids is not caused by gene movements in the Y chromosome
Année de publication
2025
Auteurs
Vanderlinde T., Uno F., Goldstein G., Sabot François, Carareto C. M. A., Vieira C., Markow T. A., Carvalho A. B.
Source
Evolution, 2025,
Early access, p. [13 p.] ISSN 0014-3820
Y chromosomes play important roles in sex determination, male fertility, and, in some cases, hybrid male sterility. Nearly 40 years ago, Zouros and co-workers found that Drosophila mojavensis males carrying a Y chromosome from the sibling species D. arizonae are sterile, with fertility restored by chromosome 4 from D. arizonae. While these findings could result from gene interactions, they may also suggest the movement of an essential male fertility gene from the Y to chromosome 4 in the D. arizonae lineage. To test this, we analyzed the Y-linked gene content of D. mojavensis, D. arizonae, and the closely related D. navojoa. We identified 5 previously unreported Y-linked genes, bringing the total to 14. These genes fit the pattern observed in other Drosophila species: they originated from autosomal, testis-specific genes that duplicated onto the Y chromosome. All Y-linked genes are shared between D. arizonae and D. mojavensis, ruling out the movement of a protein-coding gene as the cause of sterility. However, we found a huge difference in the copy number of GI26128, an HP1 gene family member, with similar to 1,400 Y-linked copies in D. arizonae but only 6 in D. mojavensis, making it a candidate to explain the hybrid male sterility.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
Localisation
Fonds IRD [F B010094972]
Identifiant IRD
fdi:010094972
