%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Vanderlinde, T.
%A Uno, F.
%A Goldstein, G.
%A Sabot, François
%A Carareto, C. M. A.
%A Vieira, C.
%A Markow, T. A.
%A Carvalho, A. B.
%T Male sterility in Drosophila mojavensis x D. arizonae hybrids is not caused by gene movements in the Y chromosome
%D 2025
%L fdi:010094972
%G ENG
%J Evolution
%@ 0014-3820
%K mojavensis cluster ; Y chromosome ; gene duplication ; hybrid sterility ; Drosophila
%M ISI:001566048100001
%P [13 ]
%R 10.1093/evolut/qpaf163
%U https://www.documentation.ird.fr/hor/fdi:010094972
%> https://www.documentation.ird.fr/intranet/publi/2025-10/010094972.pdf
%V Early access
%W Horizon (IRD)
%X Y chromosomes play important roles in sex determination, male fertility, and, in some cases, hybrid male sterility. Nearly 40 years ago, Zouros and co-workers found that Drosophila mojavensis males carrying a Y chromosome from the sibling species D. arizonae are sterile, with fertility restored by chromosome 4 from D. arizonae. While these findings could result from gene interactions, they may also suggest the movement of an essential male fertility gene from the Y to chromosome 4 in the D. arizonae lineage. To test this, we analyzed the Y-linked gene content of D. mojavensis, D. arizonae, and the closely related D. navojoa. We identified 5 previously unreported Y-linked genes, bringing the total to 14. These genes fit the pattern observed in other Drosophila species: they originated from autosomal, testis-specific genes that duplicated onto the Y chromosome. All Y-linked genes are shared between D. arizonae and D. mojavensis, ruling out the movement of a protein-coding gene as the cause of sterility. However, we found a huge difference in the copy number of GI26128, an HP1 gene family member, with similar to 1,400 Y-linked copies in D. arizonae but only 6 in D. mojavensis, making it a candidate to explain the hybrid male sterility.
%$ 020