Dewey K. G., Arnold C. D., Wessells K. R., Prado E. L., Abbeddou S., Adu-Afarwuah S., Ali H., Arnold B. F., Ashorn P., Ashorn U., Ashraf S., Becquey E., Brown K. H., Christian P., Colford J. M., Dulience S. J. L., Fernald L. C. H., Galasso E., Hallamaa L., Hess S. Y., Humphrey J. H., Huybregts L., Iannottie L. L., Jannat K., Lartey A., Le Port Agnès, Leroy J. L., Luby S. P., Maleta K., Matias S. L., Mbuya M. N. N., Mridha M. K., Nkhoma M., Null C., Paul R. R., Okronipa H., Ouedraogo J. B., Pickering A. J., Prendergast A. J., Ruel M., Shaikh S., Weber A. M., Wolff P., Zongrone A., Stewart C. P. (2022). Preventive small-quantity lipid-based nutrient supplements reduce severe wasting and severe stunting among young children : an individual participant data meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition, [Early access], p. [20 p.]. ISSN 0002-9165.
Titre du document
Preventive small-quantity lipid-based nutrient supplements reduce severe wasting and severe stunting among young children : an individual participant data meta-analysis of randomized controlled trials
Année de publication
2022
Auteurs
Dewey K. G., Arnold C. D., Wessells K. R., Prado E. L., Abbeddou S., Adu-Afarwuah S., Ali H., Arnold B. F., Ashorn P., Ashorn U., Ashraf S., Becquey E., Brown K. H., Christian P., Colford J. M., Dulience S. J. L., Fernald L. C. H., Galasso E., Hallamaa L., Hess S. Y., Humphrey J. H., Huybregts L., Iannottie L. L., Jannat K., Lartey A., Le Port Agnès, Leroy J. L., Luby S. P., Maleta K., Matias S. L., Mbuya M. N. N., Mridha M. K., Nkhoma M., Null C., Paul R. R., Okronipa H., Ouedraogo J. B., Pickering A. J., Prendergast A. J., Ruel M., Shaikh S., Weber A. M., Wolff P., Zongrone A., Stewart C. P.
Source
American Journal of Clinical Nutrition, 2022,
[Early access], p. [20 p.] ISSN 0002-9165
Background: Meta-analyses show that small-quantity lipid-based nutrient supplements (SQ-LNSs) reduce child wasting and stunting. There is little information regarding effects on severe wasting or stunting. Objectives: We aimed to identify the effect of SQ-LNSs on prevalence of severe wasting (weight-for-length z score < -3) and severe stunting (length-for-age z score < -3). Methods: We conducted a 2-stage meta-analysis of individual participant data from 14 randomized controlled trials of SQ-LNSs provided to children 6-24 mo of age. We generated study-specific and subgroup estimates of SQ-LNS compared with control and pooled the estimates using fixed-effects models. We used random-effects meta-regression to examine study-level effect modifiers. In sensitivity analyses, we examined whether results differed depending on study arm inclusion criteria and types of comparisons. Results: SQ-LNS provision led to a relative reduction of 31% in severe wasting [prevalence ratio (PR): 0.69; 95% CI: 0.55, 0.86; n = 34,373] and 17% in severe stunting (PR: 0.83; 95% CI: 0.78, 0.90; n = 36,795) at endline. Results were similar in most of the sensitivity analyses but somewhat attenuated when comparisons using passive control arms were excluded (PR: 0.74; 95% CI: 0.57, 0.96; n = 26,327 for severe wasting and PR: 0.88; 95% CI: 0.81, 0.95; n = 28,742 for severe stunting). Study-level characteristics generally did not significantly modify the effects of SQ-LNSs, but results suggested greater effects of SQ-LNSs in sites with greater burdens of wasting or stunting, or with poorer water quality or sanitation. Conclusions: Including SQ-LNSs in preventive interventions to promote healthy child growth and development is likely to reduce rates of severe wasting and stunting.
Plan de classement
Santé : généralités [050]
;
Nutrition, alimentation [054]
Description Géographique
AFRIQUE SUBSAHARIENNE ; BURKINA FASO ; GHANA ; KENYA ; MADAGASCAR ; MALAWI ; MALI ; ZIMBABWE ; HAITI ; BANGLADESH
Localisation
Fonds IRD [F B010086128]
Identifiant IRD
fdi:010086128
