%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Dewey, K. G.
%A Arnold, C. D.
%A Wessells, K. R.
%A Prado, E. L.
%A Abbeddou, S.
%A Adu-Afarwuah, S.
%A Ali, H.
%A Arnold, B. F.
%A Ashorn, P.
%A Ashorn, U.
%A Ashraf, S.
%A Becquey, E.
%A Brown, K. H.
%A Christian, P.
%A Colford, J. M.
%A Dulience, S. J. L.
%A Fernald, L. C. H.
%A Galasso, E.
%A Hallamaa, L.
%A Hess, S. Y.
%A Humphrey, J. H.
%A Huybregts, L.
%A Iannottie, L. L.
%A Jannat, K.
%A Lartey, A.
%A Le Port, Agnès
%A Leroy, J. L.
%A Luby, S. P.
%A Maleta, K.
%A Matias, S. L.
%A Mbuya, M. N. N.
%A Mridha, M. K.
%A Nkhoma, M.
%A Null, C.
%A Paul, R. R.
%A Okronipa, H.
%A Ouedraogo, J. B.
%A Pickering, A. J.
%A Prendergast, A. J.
%A Ruel, M.
%A Shaikh, S.
%A Weber, A. M.
%A Wolff, P.
%A Zongrone, A.
%A Stewart, C. P.
%T Preventive small-quantity lipid-based nutrient supplements reduce severe wasting and severe stunting among young children : an individual participant data meta-analysis of randomized controlled trials
%D 2022
%L fdi:010086128
%G ENG
%J American Journal of Clinical Nutrition
%@ 0002-9165
%K stunting ; wasting ; child undernutrition ; complementary feeding ; severe malnutrition ; home fortification
%K AFRIQUE SUBSAHARIENNE ; BURKINA FASO ; GHANA ; KENYA ; MADAGASCAR ; MALAWI ; MALI ; ZIMBABWE ; HAITI ; BANGLADESH
%M ISI:000859407100001
%P [20 ]
%R 10.1093/ajcn/nqac232
%U https://www.documentation.ird.fr/hor/fdi:010086128
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2022-11/010086128.pdf
%V [Early access]
%W Horizon (IRD)
%X Background: Meta-analyses show that small-quantity lipid-based nutrient supplements (SQ-LNSs) reduce child wasting and stunting. There is little information regarding effects on severe wasting or stunting. Objectives: We aimed to identify the effect of SQ-LNSs on prevalence of severe wasting (weight-for-length z score < -3) and severe stunting (length-for-age z score < -3). Methods: We conducted a 2-stage meta-analysis of individual participant data from 14 randomized controlled trials of SQ-LNSs provided to children 6-24 mo of age. We generated study-specific and subgroup estimates of SQ-LNS compared with control and pooled the estimates using fixed-effects models. We used random-effects meta-regression to examine study-level effect modifiers. In sensitivity analyses, we examined whether results differed depending on study arm inclusion criteria and types of comparisons. Results: SQ-LNS provision led to a relative reduction of 31% in severe wasting [prevalence ratio (PR): 0.69; 95% CI: 0.55, 0.86; n = 34,373] and 17% in severe stunting (PR: 0.83; 95% CI: 0.78, 0.90; n = 36,795) at endline. Results were similar in most of the sensitivity analyses but somewhat attenuated when comparisons using passive control arms were excluded (PR: 0.74; 95% CI: 0.57, 0.96; n = 26,327 for severe wasting and PR: 0.88; 95% CI: 0.81, 0.95; n = 28,742 for severe stunting). Study-level characteristics generally did not significantly modify the effects of SQ-LNSs, but results suggested greater effects of SQ-LNSs in sites with greater burdens of wasting or stunting, or with poorer water quality or sanitation. Conclusions: Including SQ-LNSs in preventive interventions to promote healthy child growth and development is likely to reduce rates of severe wasting and stunting.
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