@article{fdi:010086128,
  title = {{P}reventive small-quantity lipid-based nutrient supplements reduce severe wasting and severe stunting among young children : an individual participant data meta-analysis of randomized controlled trials},
  author = {{D}ewey, {K}. {G}. and {A}rnold, {C}. {D}. and {W}essells, {K}. {R}. and {P}rado, {E}. {L}. and {A}bbeddou, {S}. and {A}du-{A}farwuah, {S}. and {A}li, {H}. and {A}rnold, {B}. {F}. and {A}shorn, {P}. and {A}shorn, {U}. and {A}shraf, {S}. and {B}ecquey, {E}. and {B}rown, {K}. {H}. and {C}hristian, {P}. and {C}olford, {J}. {M}. and {D}ulience, {S}. {J}. {L}. and {F}ernald, {L}. {C}. {H}. and {G}alasso, {E}. and {H}allamaa, {L}. and {H}ess, {S}. {Y}. and {H}umphrey, {J}. {H}. and {H}uybregts, {L}. and {I}annottie, {L}. {L}. and {J}annat, {K}. and {L}artey, {A}. and {L}e {P}ort, {A}gn{\`e}s and {L}eroy, {J}. {L}. and {L}uby, {S}. {P}. and {M}aleta, {K}. and {M}atias, {S}. {L}. and {M}buya, {M}. {N}. {N}. and {M}ridha, {M}. {K}. and {N}khoma, {M}. and {N}ull, {C}. and {P}aul, {R}. {R}. and {O}kronipa, {H}. and {O}uedraogo, {J}. {B}. and {P}ickering, {A}. {J}. and {P}rendergast, {A}. {J}. and {R}uel, {M}. and {S}haikh, {S}. and {W}eber, {A}. {M}. and {W}olff, {P}. and {Z}ongrone, {A}. and {S}tewart, {C}. {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {M}eta-analyses show that small-quantity lipid-based nutrient supplements ({SQ}-{LNS}s) reduce child wasting and stunting. {T}here is little information regarding effects on severe wasting or stunting. {O}bjectives: {W}e aimed to identify the effect of {SQ}-{LNS}s on prevalence of severe wasting (weight-for-length z score < -3) and severe stunting (length-for-age z score < -3). {M}ethods: {W}e conducted a 2-stage meta-analysis of individual participant data from 14 randomized controlled trials of {SQ}-{LNS}s provided to children 6-24 mo of age. {W}e generated study-specific and subgroup estimates of {SQ}-{LNS} compared with control and pooled the estimates using fixed-effects models. {W}e used random-effects meta-regression to examine study-level effect modifiers. {I}n sensitivity analyses, we examined whether results differed depending on study arm inclusion criteria and types of comparisons. {R}esults: {SQ}-{LNS} provision led to a relative reduction of 31% in severe wasting [prevalence ratio ({PR}): 0.69; 95% {CI}: 0.55, 0.86; n = 34,373] and 17% in severe stunting ({PR}: 0.83; 95% {CI}: 0.78, 0.90; n = 36,795) at endline. {R}esults were similar in most of the sensitivity analyses but somewhat attenuated when comparisons using passive control arms were excluded ({PR}: 0.74; 95% {CI}: 0.57, 0.96; n = 26,327 for severe wasting and {PR}: 0.88; 95% {CI}: 0.81, 0.95; n = 28,742 for severe stunting). {S}tudy-level characteristics generally did not significantly modify the effects of {SQ}-{LNS}s, but results suggested greater effects of {SQ}-{LNS}s in sites with greater burdens of wasting or stunting, or with poorer water quality or sanitation. {C}onclusions: {I}ncluding {SQ}-{LNS}s in preventive interventions to promote healthy child growth and development is likely to reduce rates of severe wasting and stunting.},
  keywords = {stunting ; wasting ; child undernutrition ; complementary feeding ; severe malnutrition ; home fortification ; {AFRIQUE} {SUBSAHARIENNE} ; {BURKINA} {FASO} ; {GHANA} ; {KENYA} ; {MADAGASCAR} ; {MALAWI} ; {MALI} ; {ZIMBABWE} ; {HAITI} ; {BANGLADESH}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {C}linical {N}utrition},
  volume = {[{E}arly access]},
  numero = {},
  pages = {[20 p.]},
  ISSN = {0002-9165},
  year = {2022},
  DOI = {10.1093/ajcn/nqac232},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086128},
}