Sonon P., Tokplonou L., Sadissou I., M'po K. K. G., Glitho S. S. C., Agniwo P., Ibikounle M., Souza A. S., Massaro J. D., Gonzalez D., Tchegninougbo T., Ayitchedji A., Massougbodji A., Moreau P., Garcia André, Milet Jacqueline, Sabbagh A., Mendes C. T., Moutairou K. A., Castelli E. C., Courtin David, Donadi E. A. (2021). Human leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are associated with malaria susceptibility in the Beninese Toffin children. Infection Genetics and Evolution, 92, p. 104828 [7 p.]. ISSN 1567-1348.
Titre du document
Human leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are associated with malaria susceptibility in the Beninese Toffin children
Année de publication
2021
Auteurs
Sonon P., Tokplonou L., Sadissou I., M'po K. K. G., Glitho S. S. C., Agniwo P., Ibikounle M., Souza A. S., Massaro J. D., Gonzalez D., Tchegninougbo T., Ayitchedji A., Massougbodji A., Moreau P., Garcia André, Milet Jacqueline, Sabbagh A., Mendes C. T., Moutairou K. A., Castelli E. C., Courtin David, Donadi E. A.
Source
Infection Genetics and Evolution, 2021,
92, p. 104828 [7 p.] ISSN 1567-1348
Background: Little attention has been devoted to the role of the immunoregulatory HLA-E/-F/-G genes in malaria. We evaluated the entire HLA-E/-F/-G variability in Beninese children highly exposed to Plasmodium falciparum (P.f.) malaria. Methods: 154 unrelated children were followed-up for six months and evaluated for the presence and number of malaria episodes. HLA-E/-F/-G genes were genotyped using massively parallel sequencing. Anti P.f. antibodies were evaluated using ELISA. Results: Children carrying the G allele at HLA-F (-1499,rs183540921) showed increased P.f. asymptomatic/ symptomatic ratio, suggesting that these children experienced more asymptomatic P.f. episodes than symptomatic one. Children carrying HLA-G-UTR-03 haplotype exhibited increased risk for symptomatic P.f. episodes and showed lower IgG2 response against P.f. GLURP-R2 when compared to the non-carriers. No as-sociations were observed for the HLA-E gene. Conclusion: HLA-F associations may be related to the differential expression profiles of the encoded immuno-modulatory molecules, and the regulatory sites at the HLA-G 3 & rsquo;UTR may be associated to posttranscriptional regulation of HLA-G and to host humoral response against P.f.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
BENIN
Localisation
Fonds IRD [F B010082200]
Identifiant IRD
fdi:010082200
