@article{fdi:010082200,
  title = {{H}uman leukocyte antigen ({HLA})-{F} and -{G} gene polymorphisms and haplotypes are associated with malaria susceptibility in the {B}eninese {T}offin children},
  author = {{S}onon, {P}. and {T}okplonou, {L}. and {S}adissou, {I}. and {M}'po, {K}. {K}. {G}. and {G}litho, {S}. {S}. {C}. and {A}gniwo, {P}. and {I}bikounle, {M}. and {S}ouza, {A}. {S}. and {M}assaro, {J}. {D}. and {G}onzalez, {D}. and {T}chegninougbo, {T}. and {A}yitchedji, {A}. and {M}assougbodji, {A}. and {M}oreau, {P}. and {G}arcia, {A}ndr{\'e} and {M}ilet, {J}acqueline and {S}abbagh, {A}. and {M}endes, {C}. {T}. and {M}outairou, {K}. {A}. and {C}astelli, {E}. {C}. and {C}ourtin, {D}avid and {D}onadi, {E}. {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {L}ittle attention has been devoted to the role of the immunoregulatory {HLA}-{E}/-{F}/-{G} genes in malaria. {W}e evaluated the entire {HLA}-{E}/-{F}/-{G} variability in {B}eninese children highly exposed to {P}lasmodium falciparum ({P}.f.) malaria. {M}ethods: 154 unrelated children were followed-up for six months and evaluated for the presence and number of malaria episodes. {HLA}-{E}/-{F}/-{G} genes were genotyped using massively parallel sequencing. {A}nti {P}.f. antibodies were evaluated using {ELISA}. {R}esults: {C}hildren carrying the {G} allele at {HLA}-{F} (-1499,rs183540921) showed increased {P}.f. asymptomatic/ symptomatic ratio, suggesting that these children experienced more asymptomatic {P}.f. episodes than symptomatic one. {C}hildren carrying {HLA}-{G}-{UTR}-03 haplotype exhibited increased risk for symptomatic {P}.f. episodes and showed lower {I}g{G}2 response against {P}.f. {GLURP}-{R}2 when compared to the non-carriers. {N}o as-sociations were observed for the {HLA}-{E} gene. {C}onclusion: {HLA}-{F} associations may be related to the differential expression profiles of the encoded immuno-modulatory molecules, and the regulatory sites at the {HLA}-{G} 3 & rsquo;{UTR} may be associated to posttranscriptional regulation of {HLA}-{G} and to host humoral response against {P}.f.},
  keywords = {{HLA}-{I}b ; {P}lasmodium falciparum ; {SNV} ; {H}aplotype ; {A}ntibody ; {BENIN}},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {92},
  numero = {},
  pages = {104828 [7 p.]},
  ISSN = {1567-1348},
  year = {2021},
  DOI = {10.1016/j.meegid.2021.104828},
  URL = {https://www.documentation.ird.fr/hor/fdi:010082200},
}