%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Sonon, P.
%A Tokplonou, L.
%A Sadissou, I.
%A M'po, K. K. G.
%A Glitho, S. S. C.
%A Agniwo, P.
%A Ibikounle, M.
%A Souza, A. S.
%A Massaro, J. D.
%A Gonzalez, D.
%A Tchegninougbo, T.
%A Ayitchedji, A.
%A Massougbodji, A.
%A Moreau, P.
%A Garcia, André
%A Milet, Jacqueline
%A Sabbagh, A.
%A Mendes, C. T.
%A Moutairou, K. A.
%A Castelli, E. C.
%A Courtin, David
%A Donadi, E. A.
%T Human leukocyte antigen (HLA)-F and -G gene polymorphisms and haplotypes are associated with malaria susceptibility in the Beninese Toffin children
%D 2021
%L fdi:010082200
%G ENG
%J Infection Genetics and Evolution
%@ 1567-1348
%K HLA-Ib ; Plasmodium falciparum ; SNV ; Haplotype ; Antibody
%K BENIN
%M ISI:000660031600011
%P 104828 [7 ]
%R 10.1016/j.meegid.2021.104828
%U https://www.documentation.ird.fr/hor/fdi:010082200
%> https://www.documentation.ird.fr/intranet/publi/2021-08/010082200.pdf
%V 92
%W Horizon (IRD)
%X Background: Little attention has been devoted to the role of the immunoregulatory HLA-E/-F/-G genes in malaria. We evaluated the entire HLA-E/-F/-G variability in Beninese children highly exposed to Plasmodium falciparum (P.f.) malaria. Methods: 154 unrelated children were followed-up for six months and evaluated for the presence and number of malaria episodes. HLA-E/-F/-G genes were genotyped using massively parallel sequencing. Anti P.f. antibodies were evaluated using ELISA. Results: Children carrying the G allele at HLA-F (-1499,rs183540921) showed increased P.f. asymptomatic/ symptomatic ratio, suggesting that these children experienced more asymptomatic P.f. episodes than symptomatic one. Children carrying HLA-G-UTR-03 haplotype exhibited increased risk for symptomatic P.f. episodes and showed lower IgG2 response against P.f. GLURP-R2 when compared to the non-carriers. No as-sociations were observed for the HLA-E gene. Conclusion: HLA-F associations may be related to the differential expression profiles of the encoded immuno-modulatory molecules, and the regulatory sites at the HLA-G 3 & rsquo;UTR may be associated to posttranscriptional regulation of HLA-G and to host humoral response against P.f.
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