Chesnais Cedric, Bizet Charlotte, Campillo J. T., Njamnshi W. Y., Bopda J., Nwane P., Pion Sébastien, Njamnshi A. K., Boussinesq Michel. (2020). A second population-based cohort study in Cameroon confirms the temporal relationship between onchocerciasis and epilepsy. Open Forum Infectious Diseases, 7 (6), ofaa206 [5p.]. ISSN 2328-8957.
Titre du document
A second population-based cohort study in Cameroon confirms the temporal relationship between onchocerciasis and epilepsy
Chesnais Cedric, Bizet Charlotte, Campillo J. T., Njamnshi W. Y., Bopda J., Nwane P., Pion Sébastien, Njamnshi A. K., Boussinesq Michel
Source
Open Forum Infectious Diseases, 2020,
7 (6), ofaa206 [5p.] ISSN 2328-8957
To confirm our earlier evidence of a temporal and dose-response relationship between onchocerciasis and epilepsy, we conducted another cohort study in a different setting in Cameroon. Individuals whose Onchocerca volvulus microfilarial density (Ov-MFD) was measured in 1992-1994 when they were children were revisited in 2019 to determine if they acquired epilepsy. With reference to individuals with no microfilariae in 1992-1994, the relative risks of acquiring epilepsy were 0.96, 2.76, 3.67, and 11.87 in subjects with initial Ov-MFD of 1-7, 8-70, 71-200, and > 200 microfilariae per skin snip, respectively. This study further demonstrates reproducibility using the Bradford Hill's criteria for causality.
