%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Chesnais, Cedric
%A Bizet, Charlotte
%A Campillo, J. T.
%A Njamnshi, W. Y.
%A Bopda, J.
%A Nwane, P.
%A Pion, Sébastien
%A Njamnshi, A. K.
%A Boussinesq, Michel
%T A second population-based cohort study in Cameroon confirms the temporal relationship between onchocerciasis and epilepsy
%D 2020
%L fdi:010079569
%G ENG
%J Open Forum Infectious Diseases
%@ 2328-8957
%K onchocerciasis ; epilepsy ; causal relationship ; Africa ; cohort
%K CAMEROUN
%M ISI:000565181000039
%N 6
%P ofaa206 [5]
%R 10.1093/ofid/ofaa206
%U https://www.documentation.ird.fr/hor/fdi:010079569
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-09/010079569.pdf
%V 7
%W Horizon (IRD)
%X To confirm our earlier evidence of a temporal and dose-response relationship between onchocerciasis and epilepsy, we conducted another cohort study in a different setting in Cameroon. Individuals whose Onchocerca volvulus microfilarial density (Ov-MFD) was measured in 1992-1994 when they were children were revisited in 2019 to determine if they acquired epilepsy. With reference to individuals with no microfilariae in 1992-1994, the relative risks of acquiring epilepsy were 0.96, 2.76, 3.67, and 11.87 in subjects with initial Ov-MFD of 1-7, 8-70, 71-200, and > 200 microfilariae per skin snip, respectively. This study further demonstrates reproducibility using the Bradford Hill's criteria for causality.
%$ 052 ; 050