Rahabi M., Jacquemin G., Prat M., Meunier E., AlaEddine M., Bertrand B., Lefevre L., Benmoussa K., Batigne P., Aubouy Agnès, Auwerx J., Kirzin S., Bonnet D., Danjoux M., Pipy B., Alric L., Authier H., Coste A. (2020). Divergent roles for macrophage C-type lectin receptors, dectin-1 and mannose receptors, in the intestinal inflammatory response. Cell Reports, 30 (13), p. 4386–4398. ISSN 2211-1247.
Titre du document
Divergent roles for macrophage C-type lectin receptors, dectin-1 and mannose receptors, in the intestinal inflammatory response
Année de publication
2020
Auteurs
Rahabi M., Jacquemin G., Prat M., Meunier E., AlaEddine M., Bertrand B., Lefevre L., Benmoussa K., Batigne P., Aubouy Agnès, Auwerx J., Kirzin S., Bonnet D., Danjoux M., Pipy B., Alric L., Authier H., Coste A.
Source
Cell Reports, 2020,
30 (13), p. 4386–4398 ISSN 2211-1247
Colonic macrophages are considered to be major effectors of inflammatory bowel diseases (IBDs) and the control of gut inflammation through C-type lectin receptors is an emerging concept. We show that during colitis, the loss of dectin-1 on myeloid cells prevents intestinal inflammation, while the lack of mannose receptor (MR) exacerbates it. A marked increase in dectin-1 expression in dextran sulfate sodium (DSS)-exposed MR-deficient mice supports the critical contribution of dectin-1 to colitis outcome. Dectin-1 is crucial for Ly6C(high)CCR2(high) monocyte population enrichment in the blood and their recruitment to inflamed colon as precursors of inflammatory macrophages. Dectin-1 also promotes inflammasome-dependent interleukin-1 beta (IL-1 beta) secretion through leukotriene B4 production. Interestingly, colonic inflammation is associated with a concomitant overexpression of dectin-1/CCL2/LTA4H and downregulation of MR on macrophages from IBD patients. Thus, MR and dectin-1 on macrophages are important mucosal inflammatory regulators that contribute to the intestinal inflammation.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Santé : généralités [050]
Localisation
Fonds IRD [F B010078926]
Identifiant IRD
fdi:010078926
