%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Rahabi, M.
%A Jacquemin, G.
%A Prat, M.
%A Meunier, E.
%A AlaEddine, M.
%A Bertrand, B.
%A Lefevre, L.
%A Benmoussa, K.
%A Batigne, P.
%A Aubouy, Agnès
%A Auwerx, J.
%A Kirzin, S.
%A Bonnet, D.
%A Danjoux, M.
%A Pipy, B.
%A Alric, L.
%A Authier, H.
%A Coste, A.
%T Divergent roles for macrophage C-type lectin receptors, dectin-1 and mannose receptors, in the intestinal inflammatory response
%D 2020
%L fdi:010078926
%G ENG
%J Cell Reports
%@ 2211-1247
%M ISI:000522734200007
%N 13
%P 4386–4398
%R 10.1016/j.celrep.2020.03.018
%U https://www.documentation.ird.fr/hor/fdi:010078926
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-04/010078926.pdf
%V 30
%W Horizon (IRD)
%X Colonic macrophages are considered to be major effectors of inflammatory bowel diseases (IBDs) and the control of gut inflammation through C-type lectin receptors is an emerging concept. We show that during colitis, the loss of dectin-1 on myeloid cells prevents intestinal inflammation, while the lack of mannose receptor (MR) exacerbates it. A marked increase in dectin-1 expression in dextran sulfate sodium (DSS)-exposed MR-deficient mice supports the critical contribution of dectin-1 to colitis outcome. Dectin-1 is crucial for Ly6C(high)CCR2(high) monocyte population enrichment in the blood and their recruitment to inflamed colon as precursors of inflammatory macrophages. Dectin-1 also promotes inflammasome-dependent interleukin-1 beta (IL-1 beta) secretion through leukotriene B4 production. Interestingly, colonic inflammation is associated with a concomitant overexpression of dectin-1/CCL2/LTA4H and downregulation of MR on macrophages from IBD patients. Thus, MR and dectin-1 on macrophages are important mucosal inflammatory regulators that contribute to the intestinal inflammation.
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