Chauvet M., Tétard M., Cottrell Gilles, Aussenac Florentin, Brossier E., Denoyel L., Lohezic M., Milet Jacqueline, Tuikue Ndam Nicaise, Pineau D., Roman Jocelyne, Luty Adrian, Gamain B., Migot Nabias Florence, Merckx A. (2019). Impact of hemoglobin S trait on cell surface antibody recognition of Palsmodium falciparum - infected erythrocytes in pregnancy - associated malaria. Open Forum Infectious Diseases, 6 (4), ofz156 [8 p.]. ISSN 2328-8957.
Titre du document
Impact of hemoglobin S trait on cell surface antibody recognition of Palsmodium falciparum - infected erythrocytes in pregnancy - associated malaria
Année de publication
2019
Auteurs
Chauvet M., Tétard M., Cottrell Gilles, Aussenac Florentin, Brossier E., Denoyel L., Lohezic M., Milet Jacqueline, Tuikue Ndam Nicaise, Pineau D., Roman Jocelyne, Luty Adrian, Gamain B., Migot Nabias Florence, Merckx A.
Source
Open Forum Infectious Diseases, 2019,
6 (4), ofz156 [8 p.] ISSN 2328-8957
Background: Sickle cell trait (HbAS) confers partial protection against malaria by reducing the adhesion of Plasmodium falciparum-infected erythrocytes to host receptors, but little is known about its potential protection against placental malaria. Methods: Using flow cytometry, we assessed the recognition of HbAA and HbAS VAR2CSA-expressing infected erythrocytes, by plasma from 159 Beninese pregnant women with either HbAA (normal) or HbAS. Using multivariate linear models adjusted for gravidity, parasite infection at delivery, glucose-6-phosphate dehydrogenase deficiency, and α-thalassemia carriage, we observed significantly reduced cell surface antibody binding of HbAS-infected erythrocytes by plasma from HbAS compared with HbAA women (P < 10–3). Results: The difference in cell surface antibody binding was only observed when infected erythrocytes and plasma were associated according to the same hemoglobin genotype. Similar levels of VAR2CSA-specific antibody were measured by enzyme-linked immunosorbent assay in the 2 groups, suggesting that the altered interaction between VAR2CSA and HbAS women's antibodies could reflect abnormal display of VAR2CSA on HbAS erythrocytes. Conclusions: Our data stress the need for assessments of erythrocyte disorders such as the sickle cell trait in a population group when studying immunological responses to P falciparum.
Plan de classement
Biologie [020BIOL]
;
Médecine [050MEDECI]
;
Lutte [052ANOPAL04]
Descripteurs
PALUDISME ; IMMUNOLOGIE ; FEMME ; GROSSESSE ; BIOLOGIE MOLECULAIRE ; CYTOMETRIE DE FLUX ; HEMOGLOBINE
Description Géographique
BENIN
Localisation
Fonds IRD [F B010076291]
Identifiant IRD
fdi:010076291
