@article{fdi:010076291,
  title = {{I}mpact of hemoglobin {S} trait on cell surface antibody recognition of {P}alsmodium falciparum - infected erythrocytes in pregnancy - associated malaria},
  author = {{C}hauvet, {M}. and {T}{\'e}tard, {M}. and {C}ottrell, {G}illes and {A}ussenac, {F}lorentin and {B}rossier, {E}. and {D}enoyel, {L}. and {L}ohezic, {M}. and {M}ilet, {J}acqueline and {T}uikue {N}dam, {N}icaise and {P}ineau, {D}. and {R}oman, {J}ocelyne and {L}uty, {A}drian and {G}amain, {B}. and {M}igot {N}abias, {F}lorence and {M}erckx, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {S}ickle cell trait ({H}b{AS}) confers partial protection against malaria by reducing the adhesion of {P}lasmodium falciparum-infected erythrocytes to host receptors, but little is known about its potential protection against placental malaria. {M}ethods: {U}sing flow cytometry, we assessed the recognition of {H}b{AA} and {H}b{AS} {VAR}2{CSA}-expressing infected erythrocytes, by plasma from 159 {B}eninese pregnant women with either {H}b{AA} (normal) or {H}b{AS}. {U}sing multivariate linear models adjusted for gravidity, parasite infection at delivery, glucose-6-phosphate dehydrogenase deficiency, and α-thalassemia carriage, we observed significantly reduced cell surface antibody binding of {H}b{AS}-infected erythrocytes by plasma from {H}b{AS} compared with {H}b{AA} women ({P} < 10–3). {R}esults: {T}he difference in cell surface antibody binding was only observed when infected erythrocytes and plasma were associated according to the same hemoglobin genotype. {S}imilar levels of {VAR}2{CSA}-specific antibody were measured by enzyme-linked immunosorbent assay in the 2 groups, suggesting that the altered interaction between {VAR}2{CSA} and {H}b{AS} women's antibodies could reflect abnormal display of {VAR}2{CSA} on {H}b{AS} erythrocytes. {C}onclusions: {O}ur data stress the need for assessments of erythrocyte disorders such as the sickle cell trait in a population group when studying immunological responses to {P} falciparum.},
  keywords = {{PALUDISME} ; {IMMUNOLOGIE} ; {FEMME} ; {GROSSESSE} ; {BIOLOGIE} {MOLECULAIRE} ; {CYTOMETRIE} {DE} {FLUX} ; {HEMOGLOBINE} ; {BENIN}},
  booktitle = {},
  journal = {{O}pen {F}orum {I}nfectious {D}iseases},
  volume = {6},
  numero = {4},
  pages = {ofz156 [8 ]},
  ISSN = {2328-8957},
  year = {2019},
  DOI = {10.1093/ofid/ofz156},
  URL = {https://www.documentation.ird.fr/hor/fdi:010076291},
}