Sonon P., Sadissou I., Tokplonou L., M'po K. K. G., Glitho S. S. C., Agniwo P., Ibikounle M., Massaro J. D., Massougbodji A., Moreau P., Sabbagh A., Mendes C. T., Moutairou K. A., Castelli E. C., Courtin David, Donadi E. A. (2018). HLA-G, -E and -F regulatory and coding region variability and haplotypes in the Beninese Toffin population sample. Molecular Immunology, 104, p. 108-127. ISSN 0161-5890.
Titre du document
HLA-G, -E and -F regulatory and coding region variability and haplotypes in the Beninese Toffin population sample
Année de publication
2018
Auteurs
Sonon P., Sadissou I., Tokplonou L., M'po K. K. G., Glitho S. S. C., Agniwo P., Ibikounle M., Massaro J. D., Massougbodji A., Moreau P., Sabbagh A., Mendes C. T., Moutairou K. A., Castelli E. C., Courtin David, Donadi E. A.
Source
Molecular Immunology, 2018,
104, p. 108-127 ISSN 0161-5890
HLA-G/E/F genes exhibit immunomodulatory properties and are expressed in placenta. Little attention has been devoted to the study of these genes in sub-Saharan African populations, which are yet the most diverse. To fill this gap, we evaluated the complete gene variability, approximately 5.1 kb for HLA-G (n = 149), 7.7 kb for HLAE (n = 150) and 6.2 kb for HLA-P (n = 152) in the remote Beninese Toffin population, using massive parallel sequencing. Overall, 96, 37 and 68 variable sites were detected along the entire HLA-G,-E and-F, respectively, arranged into region-specific haplotypes; i.e., promoter haplotypes (16, 19, and 15 respectively), coding haplotypes (19, 15, and 29 respectively), 3' untranslated region (3'UTR) haplotypes (12, 7 and 2, respectively) and extended haplotypes (33, 31 and 32 respectively). All promoter/coding/3'UTR haplotypes followed the patterns already described in worldwide populations. HLA-E was the most conserved, exhibiting mainly two full-length encoded-molecules (E*01:01 and E*01:03), followed by HLA-F, three full-length proteins (F*01:01, F*01:02 and F*01:03) and HLA-G, four proteins: three full-length (G*01:01, G*01:03 and G*01:04) and one truncated (G*01:05N). Although HLA-G/E/F alleles in the Toffin population were the most frequently observed worldwide, the frequencies of the coding haplotypes were closely similar to those described for other African populations (Guinea-Conakry and Burkina-Faso), when compared to non-African ones (Brazilian), indicating that variable sites along these genes were present in Africa before human dispersion.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Santé : généralités [050]
Description Géographique
BENIN
Localisation
Fonds IRD [F B010074796]
Identifiant IRD
fdi:010074796
