@article{fdi:010074796,
  title = {{HLA}-{G}, -{E} and -{F} regulatory and coding region variability and haplotypes in the {B}eninese {T}offin population sample},
  author = {{S}onon, {P}. and {S}adissou, {I}. and {T}okplonou, {L}. and {M}'po, {K}. {K}. {G}. and {G}litho, {S}. {S}. {C}. and {A}gniwo, {P}. and {I}bikounle, {M}. and {M}assaro, {J}. {D}. and {M}assougbodji, {A}. and {M}oreau, {P}. and {S}abbagh, {A}. and {M}endes, {C}. {T}. and {M}outairou, {K}. {A}. and {C}astelli, {E}. {C}. and {C}ourtin, {D}avid and {D}onadi, {E}. {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{HLA}-{G}/{E}/{F} genes exhibit immunomodulatory properties and are expressed in placenta. {L}ittle attention has been devoted to the study of these genes in sub-{S}aharan {A}frican populations, which are yet the most diverse. {T}o fill this gap, we evaluated the complete gene variability, approximately 5.1 kb for {HLA}-{G} (n = 149), 7.7 kb for {HLAE} (n = 150) and 6.2 kb for {HLA}-{P} (n = 152) in the remote {B}eninese {T}offin population, using massive parallel sequencing. {O}verall, 96, 37 and 68 variable sites were detected along the entire {HLA}-{G},-{E} and-{F}, respectively, arranged into region-specific haplotypes; i.e., promoter haplotypes (16, 19, and 15 respectively), coding haplotypes (19, 15, and 29 respectively), 3' untranslated region (3'{UTR}) haplotypes (12, 7 and 2, respectively) and extended haplotypes (33, 31 and 32 respectively). {A}ll promoter/coding/3'{UTR} haplotypes followed the patterns already described in worldwide populations. {HLA}-{E} was the most conserved, exhibiting mainly two full-length encoded-molecules ({E}*01:01 and {E}*01:03), followed by {HLA}-{F}, three full-length proteins ({F}*01:01, {F}*01:02 and {F}*01:03) and {HLA}-{G}, four proteins: three full-length ({G}*01:01, {G}*01:03 and {G}*01:04) and one truncated ({G}*01:05{N}). {A}lthough {HLA}-{G}/{E}/{F} alleles in the {T}offin population were the most frequently observed worldwide, the frequencies of the coding haplotypes were closely similar to those described for other {A}frican populations ({G}uinea-{C}onakry and {B}urkina-{F}aso), when compared to non-{A}frican ones ({B}razilian), indicating that variable sites along these genes were present in {A}frica before human dispersion.},
  keywords = {{HLA}-{E} ; {HLA}-{F} ; {HLA}-{G} ; {H}aplotypes ; {M}assive parallel sequencing ; {A}frican ; {BENIN}},
  booktitle = {},
  journal = {{M}olecular {I}mmunology},
  volume = {104},
  numero = {},
  pages = {108--127},
  ISSN = {0161-5890},
  year = {2018},
  DOI = {10.1016/j.molimm.2018.08.016},
  URL = {https://www.documentation.ird.fr/hor/fdi:010074796},
}