Low A.J., Clayton T., Konate I., Nagot N., Ouedraogo A., Huet C., Didelot-Rousseau M., Segondy M., Van de Perre P., Mayaud P., Yérélon Cohort Study Group (collab.), Becquart Pierre (collab.). (2011). Genital warts and infection with human immunodeficiency virus in high-risk women in Burkina Faso : a longitudinal study. BMC Infectious Diseases, 11, art. no 20 [9 p. en ligne]. ISSN 1471-2334.
Titre du document
Genital warts and infection with human immunodeficiency virus in high-risk women in Burkina Faso : a longitudinal study
Année de publication
2011
Auteurs
Low A.J., Clayton T., Konate I., Nagot N., Ouedraogo A., Huet C., Didelot-Rousseau M., Segondy M., Van de Perre P., Mayaud P., Yérélon Cohort Study Group, Becquart Pierre (collab.)
Source
BMC Infectious Diseases, 2011,
11, art. no 20 [9 p. en ligne] ISSN 1471-2334
Background: Human papillomaviruses are the most common sexually transmitted infections, and genital warts, caused by HPV-6 and 11, entail considerable morbidity and cost. The natural history of genital warts in relation to HIV-1 infection has not been described in African women. We examined risk factors for genital warts in a cohort of high-risk women in Burkina Faso, in order to further describe their epidemiology. Methods: A prospective study of 765 high-risk women who were followed at 4-monthly intervals for 27 months in Burkina Faso. Logistic and Cox regression were used to identify factors associated with prevalent, incident and persistent genital warts, including HIV-1 serostatus, CD4+ count, and concurrent sexually transmitted infections. In a subset of 306 women, cervical HPV DNA was tested at enrolment. Results: Genital wart prevalence at baseline was 1.6% (8/492) among HIV-uninfected and 7.0% (19/273) among HIV-1 seropositive women. Forty women (5.2%) experienced at least one incident GW episode. Incidence was 1.1 per 100 person-years among HIV-uninfected women, 7.4 per 100 person-years among HIV-1 seropositive women with a nadir CD4+ count >200 cells/mu L and 14.6 per 100 person-years among HIV-1 seropositive women with a nadir CD4+ count <= 200 cells/mu L. Incident genital warts were also associated with concurrent bacterial vaginosis, and genital ulceration. Antiretroviral therapy was not protective against incident or persistent genital warts. Detection of HPV-6 DNA and abnormal cervical cytology were strongly associated with incident genital warts. Conclusions: Genital warts occur much more frequently among HIV-1 infected women in Africa, particularly among those with low CD4+ counts. Antiretroviral therapy did not reduce the incidence or persistence of genital warts in this population.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
BURKINA FASO
Localisation
Fonds IRD [F B010069944]
Identifiant IRD
fdi:010069944
