@article{fdi:010069944,
  title = {{G}enital warts and infection with human immunodeficiency virus in high-risk women in {B}urkina {F}aso : a longitudinal study},
  author = {{L}ow, {A}.{J}. and {C}layton, {T}. and {K}onate, {I}. and {N}agot, {N}. and {O}uedraogo, {A}. and {H}uet, {C}. and {D}idelot-{R}ousseau, {M}. and {S}egondy, {M}. and {V}an de {P}erre, {P}. and {M}ayaud, {P}. and {Y}{\'e}r{\'e}lon {C}ohort {S}tudy {G}roup and {B}ecquart, {P}ierre},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {H}uman papillomaviruses are the most common sexually transmitted infections, and genital warts, caused by {HPV}-6 and 11, entail considerable morbidity and cost. {T}he natural history of genital warts in relation to {HIV}-1 infection has not been described in {A}frican women. {W}e examined risk factors for genital warts in a cohort of high-risk women in {B}urkina {F}aso, in order to further describe their epidemiology. {M}ethods: {A} prospective study of 765 high-risk women who were followed at 4-monthly intervals for 27 months in {B}urkina {F}aso. {L}ogistic and {C}ox regression were used to identify factors associated with prevalent, incident and persistent genital warts, including {HIV}-1 serostatus, {CD}4+ count, and concurrent sexually transmitted infections. {I}n a subset of 306 women, cervical {HPV} {DNA} was tested at enrolment. {R}esults: {G}enital wart prevalence at baseline was 1.6% (8/492) among {HIV}-uninfected and 7.0% (19/273) among {HIV}-1 seropositive women. {F}orty women (5.2%) experienced at least one incident {GW} episode. {I}ncidence was 1.1 per 100 person-years among {HIV}-uninfected women, 7.4 per 100 person-years among {HIV}-1 seropositive women with a nadir {CD}4+ count >200 cells/mu {L} and 14.6 per 100 person-years among {HIV}-1 seropositive women with a nadir {CD}4+ count <= 200 cells/mu {L}. {I}ncident genital warts were also associated with concurrent bacterial vaginosis, and genital ulceration. {A}ntiretroviral therapy was not protective against incident or persistent genital warts. {D}etection of {HPV}-6 {DNA} and abnormal cervical cytology were strongly associated with incident genital warts. {C}onclusions: {G}enital warts occur much more frequently among {HIV}-1 infected women in {A}frica, particularly among those with low {CD}4+ counts. {A}ntiretroviral therapy did not reduce the incidence or persistence of genital warts in this population.},
  keywords = {{BURKINA} {FASO}},
  booktitle = {},
  journal = {{BMC} {I}nfectious {D}iseases},
  volume = {11},
  numero = {},
  pages = {art. no 20 [9  en ligne]},
  ISSN = {1471-2334},
  year = {2011},
  DOI = {10.1186/1471-2334-11-20},
  URL = {https://www.documentation.ird.fr/hor/fdi:010069944},
}