%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Low, A.J.
%A Clayton, T.
%A Konate, I.
%A Nagot, N.
%A Ouedraogo, A.
%A Huet, C.
%A Didelot-Rousseau, M.
%A Segondy, M.
%A Van de Perre, P.
%A Mayaud, P.
%A Yérélon Cohort Study Group
%A Becquart, Pierre
%T Genital warts and infection with human immunodeficiency virus in high-risk women in Burkina Faso : a longitudinal study
%D 2011
%L fdi:010069944
%G ENG
%J BMC Infectious Diseases
%@ 1471-2334
%K BURKINA FASO
%M ISI:000286732000001
%P art. no 20 [9  en ligne]
%R 10.1186/1471-2334-11-20
%U https://www.documentation.ird.fr/hor/fdi:010069944
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-06/010069944.pdf
%V 11
%W Horizon (IRD)
%X Background: Human papillomaviruses are the most common sexually transmitted infections, and genital warts, caused by HPV-6 and 11, entail considerable morbidity and cost. The natural history of genital warts in relation to HIV-1 infection has not been described in African women. We examined risk factors for genital warts in a cohort of high-risk women in Burkina Faso, in order to further describe their epidemiology. Methods: A prospective study of 765 high-risk women who were followed at 4-monthly intervals for 27 months in Burkina Faso. Logistic and Cox regression were used to identify factors associated with prevalent, incident and persistent genital warts, including HIV-1 serostatus, CD4+ count, and concurrent sexually transmitted infections. In a subset of 306 women, cervical HPV DNA was tested at enrolment. Results: Genital wart prevalence at baseline was 1.6% (8/492) among HIV-uninfected and 7.0% (19/273) among HIV-1 seropositive women. Forty women (5.2%) experienced at least one incident GW episode. Incidence was 1.1 per 100 person-years among HIV-uninfected women, 7.4 per 100 person-years among HIV-1 seropositive women with a nadir CD4+ count >200 cells/mu L and 14.6 per 100 person-years among HIV-1 seropositive women with a nadir CD4+ count <= 200 cells/mu L. Incident genital warts were also associated with concurrent bacterial vaginosis, and genital ulceration. Antiretroviral therapy was not protective against incident or persistent genital warts. Detection of HPV-6 DNA and abnormal cervical cytology were strongly associated with incident genital warts. Conclusions: Genital warts occur much more frequently among HIV-1 infected women in Africa, particularly among those with low CD4+ counts. Antiretroviral therapy did not reduce the incidence or persistence of genital warts in this population.
%$ 052