Hamel Rodolphe, Ferraris Pauline, Wichit Sineewanlaya, Diop Fodé, Talignani L., Pompon Julien, Garcia Déborah, Liégeois Florian, Sall A.A., Yssel H., Missé Dorothée. (2017). African and Asian Zika virus strains differentially induce early antiviral responses in primary human astrocytes. Infection, Genetics and Evolution, 49, p. 134-137. ISSN 1567-1348.
Titre du document
African and Asian Zika virus strains differentially induce early antiviral responses in primary human astrocytes
Année de publication
2017
Auteurs
Hamel Rodolphe, Ferraris Pauline, Wichit Sineewanlaya, Diop Fodé, Talignani L., Pompon Julien, Garcia Déborah, Liégeois Florian, Sall A.A., Yssel H., Missé Dorothée
Source
Infection, Genetics and Evolution, 2017,
49, p. 134-137 ISSN 1567-1348
ZIKA virus (ZIKV) is a newly emerging arbovirus. Since its discovery 60 years ago in Uganda, it has spread throughout the Pacific, Latin America and the Caribbean, emphasizing the capacity of ZIKV to spread to non-endemic regions worldwide. Although infection with ZIKV often leads to mild disease, its recent emergence in the Americas has coincidedwith an increase in adults developing Guillain-Barre syndrome and neurological complications in new-borns, such as congenitalmicrocephaly. Many questions remain unanswered regarding the complications caused by different primary isolates of ZIKV. Here, we report the permissiveness of primary human astrocytes for two clinically relevant, Asian and African ZIKV strains and show that both isolates strongly induce antiviral immune responses in these cells albeitwith markedly different kinetics. This study describes for the first time the specific antiviral gene expression in infected primary human astrocytes, the major glial cells within the central nervous system.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010069552]
Identifiant IRD
fdi:010069552
