@article{fdi:010069552,
  title = {{A}frican and {A}sian {Z}ika virus strains differentially induce early antiviral responses in primary human astrocytes},
  author = {{H}amel, {R}odolphe and {F}erraris, {P}auline and {W}ichit, {S}ineewanlaya and {D}iop, {F}od{\'e} and {T}alignani, {L}. and {P}ompon, {J}ulien and {G}arcia, {D}{\'e}borah and {L}i{\'e}geois, {F}lorian and {S}all, {A}.{A}. and {Y}ssel, {H}. and {M}iss{\'e}, {D}oroth{\'e}e},
  editor = {},
  language = {{ENG}},
  abstract = {{ZIKA} virus ({ZIKV}) is a newly emerging arbovirus. {S}ince its discovery 60 years ago in {U}ganda, it has spread throughout the {P}acific, {L}atin {A}merica and the {C}aribbean, emphasizing the capacity of {ZIKV} to spread to non-endemic regions worldwide. {A}lthough infection with {ZIKV} often leads to mild disease, its recent emergence in the {A}mericas has coincidedwith an increase in adults developing {G}uillain-{B}arre syndrome and neurological complications in new-borns, such as congenitalmicrocephaly. {M}any questions remain unanswered regarding the complications caused by different primary isolates of {ZIKV}. {H}ere, we report the permissiveness of primary human astrocytes for two clinically relevant, {A}sian and {A}frican {ZIKV} strains and show that both isolates strongly induce antiviral immune responses in these cells albeitwith markedly different kinetics. {T}his study describes for the first time the specific antiviral gene expression in infected primary human astrocytes, the major glial cells within the central nervous system.},
  keywords = {{AFRIQUE} ; {ASIE}},
  booktitle = {},
  journal = {{I}nfection, {G}enetics and {E}volution},
  volume = {49},
  numero = {},
  pages = {134--137},
  ISSN = {1567-1348},
  year = {2017},
  URL = {https://www.documentation.ird.fr/hor/fdi:010069552},
}