Hamel Rodolphe auteur aut IRD Ferraris Pauline auteur aut IRD Wichit Sineewanlaya auteur aut IRD Diop Fodé auteur aut IRD Talignani L. auteur aut IRD Pompon Julien auteur aut IRD Garcia Déborah auteur aut IRD Liégeois Florian auteur aut IRD Sall A.A. auteur aut IRD Yssel H. auteur aut IRD Missé Dorothée auteur aut IRD text journalArticle eng text/pdf born digital access ZIKA virus (ZIKV) is a newly emerging arbovirus. Since its discovery 60 years ago in Uganda, it has spread throughout the Pacific, Latin America and the Caribbean, emphasizing the capacity of ZIKV to spread to non-endemic regions worldwide. Although infection with ZIKV often leads to mild disease, its recent emergence in the Americas has coincidedwith an increase in adults developing Guillain-Barre syndrome and neurological complications in new-borns, such as congenitalmicrocephaly. Many questions remain unanswered regarding the complications caused by different primary isolates of ZIKV. Here, we report the permissiveness of primary human astrocytes for two clinically relevant, Asian and African ZIKV strains and show that both isolates strongly induce antiviral immune responses in these cells albeitwith markedly different kinetics. This study describes for the first time the specific antiviral gene expression in infected primary human astrocytes, the major glial cells within the central nervous system. specialized AFRIQUE ASIE 052 050 49 134-137 2017 1567-1348 https://www.documentation.ird.fr/hor/fdi:010069552 1567-1348 [F B010069552] https://www.documentation.ird.fr/hor/fdi:010069552 https://www.documentation.ird.fr/intranet/publi/depot/2017-03-28/010069552.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2017-03-28 2022-03-31 fdi:010069552 fre