Berthier D., Brenière Simone Frédérique, Bras Goncalves Rachel, Lemesre Jean-Loup, Jamonneau Vincent, Solano Philippe, Lejon Veerle, Thévenon S., Bucheton Bruno. (2016). Tolerance to trypanosomatids : a threat, or a key for disease elimination ?. Trends in Parasitology, 32 (2), p. 157-168. ISSN 1471-4922.
Titre du document
Tolerance to trypanosomatids : a threat, or a key for disease elimination ?
Année de publication
2016
Type de document
Article
Auteurs
Berthier D., Brenière Simone Frédérique, Bras Goncalves Rachel, Lemesre Jean-Loup, Jamonneau Vincent, Solano Philippe, Lejon Veerle, Thévenon S., Bucheton Bruno
Source
Trends in Parasitology, 2016,
32 (2), p. 157-168 ISSN 1471-4922
So far, research on trypanosomatid infections has been driven by 'disease by disease' approaches, leading to different concepts and control strategies. It is, however, increasingly clear that they share common features such as the ability to generate long-lasting asymptomatic infections in their mammalian hosts. Trypanotolerance, long integrated in animal African trypanosomiasis control, historically refers to the ability of cattle breeds to limit Trypanosoma infection and pathology, but has only recently been recognized in humans. Whilst trypanotolerance is absent from the vocabulary on leishmaniasis and Chagas disease, asymptomatic infections also occur. We review the concept of trypanotolerance across the trypanosomatids and discuss the importance of asymptomatic carriage in the current context of elimination.
