Publications des scientifiques de l'IRD

Chippaux Jean-Philippe, Boyer L. V., Alagon A. (2015). Post-exposure treatment of Ebola virus using passive immunotherapy : proposal for a new strategy. Journal of Venomous Animals and Toxins Including Tropical Diseases, 21, p. art. 3 [7 p.]. ISSN 1678-9199.

Titre du document
Post-exposure treatment of Ebola virus using passive immunotherapy : proposal for a new strategy
Année de publication
2015
Type de document
Article référencé dans le Web of Science WOS:000350385400001
Auteurs
Chippaux Jean-Philippe, Boyer L. V., Alagon A.
Source
Journal of Venomous Animals and Toxins Including Tropical Diseases, 2015, 21, p. art. 3 [7 p.] ISSN 1678-9199
Background: Better treatments are urgently needed for the management of Ebola virus epidemics in Equatorial Africa. Methods: We conducted a systematic review of the literature on the use of passive immunotherapy for the treatment or prevention of Ebola virus disease. We placed findings from this review into the context of passive immunotherapy currently used for venom-induced disease, and recent improvements in manufacturing of polyvalent antivenom products. Results: Passive immunotherapy appears to be one of the most promising specific treatments for Ebola. However, its potential has been incompletely evaluated, considering the overall experience and recent improvement of immunotherapy. Development and use of heterologous serum derivatives could protect people exposed to Ebola viruses with reasonable cost and logistics. Conclusion: Hyperimmune equine IgG fragments and purified polyclonal whole IgG deserve further consideration as treatment for exposure to the Ebola virus.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
AFRIQUE SUBSAHARIENNE
Localisation
Fonds IRD [F B010064012]
Identifiant IRD
fdi:010064012
Contact