@article{fdi:010064012,
  title = {{P}ost-exposure treatment of {E}bola virus using passive immunotherapy : proposal for a new strategy},
  author = {{C}hippaux, {J}ean-{P}hilippe and {B}oyer, {L}. {V}. and {A}lagon, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {B}etter treatments are urgently needed for the management of {E}bola virus epidemics in {E}quatorial {A}frica. {M}ethods: {W}e conducted a systematic review of the literature on the use of passive immunotherapy for the treatment or prevention of {E}bola virus disease. {W}e placed findings from this review into the context of passive immunotherapy currently used for venom-induced disease, and recent improvements in manufacturing of polyvalent antivenom products. {R}esults: {P}assive immunotherapy appears to be one of the most promising specific treatments for {E}bola. {H}owever, its potential has been incompletely evaluated, considering the overall experience and recent improvement of immunotherapy. {D}evelopment and use of heterologous serum derivatives could protect people exposed to {E}bola viruses with reasonable cost and logistics. {C}onclusion: {H}yperimmune equine {I}g{G} fragments and purified polyclonal whole {I}g{G} deserve further consideration as treatment for exposure to the {E}bola virus.},
  keywords = {{E}bola ; {E}pidemics ; {I}mmunotherapy ; {P}rophylaxis ; {A}frica ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{J}ournal of {V}enomous {A}nimals and {T}oxins {I}ncluding {T}ropical {D}iseases},
  volume = {21},
  numero = {},
  pages = {art. 3 [7 p.]},
  ISSN = {1678-9199},
  year = {2015},
  DOI = {10.1186/s40409-015-0003-1},
  URL = {https://www.documentation.ird.fr/hor/fdi:010064012},
}