Chippaux Jean-Philippe auteur aut IRD Boyer L. V. auteur aut IRD Alagon A. auteur aut IRD text journalArticle eng text/pdf born digital access Background: Better treatments are urgently needed for the management of Ebola virus epidemics in Equatorial Africa. Methods: We conducted a systematic review of the literature on the use of passive immunotherapy for the treatment or prevention of Ebola virus disease. We placed findings from this review into the context of passive immunotherapy currently used for venom-induced disease, and recent improvements in manufacturing of polyvalent antivenom products. Results: Passive immunotherapy appears to be one of the most promising specific treatments for Ebola. However, its potential has been incompletely evaluated, considering the overall experience and recent improvement of immunotherapy. Development and use of heterologous serum derivatives could protect people exposed to Ebola viruses with reasonable cost and logistics. Conclusion: Hyperimmune equine IgG fragments and purified polyclonal whole IgG deserve further consideration as treatment for exposure to the Ebola virus. specialized Ebola Epidemics Immunotherapy Prophylaxis Africa AFRIQUE SUBSAHARIENNE 052 050 21 art. 3 [7 p.] 2015 1678-9199 https://www.documentation.ird.fr/hor/fdi:010064012 10.1186/s40409-015-0003-1 1678-9199 [F B010064012] https://www.documentation.ird.fr/hor/fdi:010064012 https://www.documentation.ird.fr/intranet/publi/2015/04/010064012.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2015-05-04 2017-08-23 fdi:010064012 fre