Kluge S. F., Mack K., Iyer S. S., Pujol F. M., Heigele A., Learn G. H., Usmani S. M., Sauter D., Joas S., Hotter D., Bibollet-Ruche F., Plenderleith L. J., Peeters Martine, Geyer M., Sharp P. M., Fackler O. T., Hahn B. H., Kirchhoff F. (2014). Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin. Cell Host and Microbe, 16 (5), p. 639-650. ISSN 1931-3128.
Titre du document
Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin
Année de publication
2014
Auteurs
Kluge S. F., Mack K., Iyer S. S., Pujol F. M., Heigele A., Learn G. H., Usmani S. M., Sauter D., Joas S., Hotter D., Bibollet-Ruche F., Plenderleith L. J., Peeters Martine, Geyer M., Sharp P. M., Fackler O. T., Hahn B. H., Kirchhoff F.
Source
Cell Host and Microbe, 2014,
16 (5), p. 639-650 ISSN 1931-3128
Most simian immunodeficiency viruses use their Nef protein to antagonize the host restriction factor tetherin. A deletion in human tetherin confers Nef resistance, representing a hurdle to successful zoonotic transmission. HIV-1 group M evolved to utilize the viral protein U (Vpu) to counteract tetherin. Although HIV-1 group O has spread epidemically in humans, it has not evolved a Vpu-based tetherin antagonism. Here we show that HIV-1 group O Nef targets a region adjacent to this deletion to inhibit transport of human tetherin to the cell surface, enhances virion release, and increases viral resistance to inhibition by interferon-alpha. The Nef protein of the inferred common ancestor of group O viruses is also active against human tetherin. Thus, Nef-mediated antagonism of human tetherin evolved prior to the spread of HIV-1 group O and likely facilitated secondary virus transmission. Our results may explain the epidemic spread of HIV-1 group O.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010062948]
Identifiant IRD
fdi:010062948
