%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Kluge, S. F.
%A Mack, K.
%A Iyer, S. S.
%A Pujol, F. M.
%A Heigele, A.
%A Learn, G. H.
%A Usmani, S. M.
%A Sauter, D.
%A Joas, S.
%A Hotter, D.
%A Bibollet-Ruche, F.
%A Plenderleith, L. J.
%A Peeters, Martine
%A Geyer, M.
%A Sharp, P. M.
%A Fackler, O. T.
%A Hahn, B. H.
%A Kirchhoff, F.
%T Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin
%D 2014
%L fdi:010062948
%G ENG
%J Cell Host and Microbe
%@ 1931-3128
%M ISI:000345123900014
%N 5
%P 639-650
%R 10.1016/j.chom.2014.10.002
%U https://www.documentation.ird.fr/hor/fdi:010062948
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers16-12/010062748.pdf
%V 16
%W Horizon (IRD)
%X Most simian immunodeficiency viruses use their Nef protein to antagonize the host restriction factor tetherin. A deletion in human tetherin confers Nef resistance, representing a hurdle to successful zoonotic transmission. HIV-1 group M evolved to utilize the viral protein U (Vpu) to counteract tetherin. Although HIV-1 group O has spread epidemically in humans, it has not evolved a Vpu-based tetherin antagonism. Here we show that HIV-1 group O Nef targets a region adjacent to this deletion to inhibit transport of human tetherin to the cell surface, enhances virion release, and increases viral resistance to inhibition by interferon-alpha. The Nef protein of the inferred common ancestor of group O viruses is also active against human tetherin. Thus, Nef-mediated antagonism of human tetherin evolved prior to the spread of HIV-1 group O and likely facilitated secondary virus transmission. Our results may explain the epidemic spread of HIV-1 group O.
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