@article{fdi:010062948,
  title = {{N}ef proteins of epidemic {HIV}-1 group {O} strains antagonize human tetherin},
  author = {{K}luge, {S}. {F}. and {M}ack, {K}. and {I}yer, {S}. {S}. and {P}ujol, {F}. {M}. and {H}eigele, {A}. and {L}earn, {G}. {H}. and {U}smani, {S}. {M}. and {S}auter, {D}. and {J}oas, {S}. and {H}otter, {D}. and {B}ibollet-{R}uche, {F}. and {P}lenderleith, {L}. {J}. and {P}eeters, {M}artine and {G}eyer, {M}. and {S}harp, {P}. {M}. and {F}ackler, {O}. {T}. and {H}ahn, {B}. {H}. and {K}irchhoff, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}ost simian immunodeficiency viruses use their {N}ef protein to antagonize the host restriction factor tetherin. {A} deletion in human tetherin confers {N}ef resistance, representing a hurdle to successful zoonotic transmission. {HIV}-1 group {M} evolved to utilize the viral protein {U} ({V}pu) to counteract tetherin. {A}lthough {HIV}-1 group {O} has spread epidemically in humans, it has not evolved a {V}pu-based tetherin antagonism. {H}ere we show that {HIV}-1 group {O} {N}ef targets a region adjacent to this deletion to inhibit transport of human tetherin to the cell surface, enhances virion release, and increases viral resistance to inhibition by interferon-alpha. {T}he {N}ef protein of the inferred common ancestor of group {O} viruses is also active against human tetherin. {T}hus, {N}ef-mediated antagonism of human tetherin evolved prior to the spread of {HIV}-1 group {O} and likely facilitated secondary virus transmission. {O}ur results may explain the epidemic spread of {HIV}-1 group {O}.},
  keywords = {},
  booktitle = {},
  journal = {{C}ell {H}ost and {M}icrobe},
  volume = {16},
  numero = {5},
  pages = {639--650},
  ISSN = {1931-3128},
  year = {2014},
  DOI = {10.1016/j.chom.2014.10.002},
  URL = {https://www.documentation.ird.fr/hor/fdi:010062948},
}