Ndiaye H. D., Tchiakpe E., Vidal Nicole, Ndiaye O., Diop A. K., Peeters Martine, Mboup S., Toure-Kane C. (2013). HIV Type 1 subtype C remains the predominant subtype in men having sex with men in Senegal. Aids Research and Human Retroviruses, 29 (9), p. 1265-1272. ISSN 0889-2229.
Titre du document
HIV Type 1 subtype C remains the predominant subtype in men having sex with men in Senegal
Ndiaye H. D., Tchiakpe E., Vidal Nicole, Ndiaye O., Diop A. K., Peeters Martine, Mboup S., Toure-Kane C.
Source
Aids Research and Human Retroviruses, 2013,
29 (9), p. 1265-1272 ISSN 0889-2229
HIV-1 epidemics are expanding among men who have sex with men in low-and middle-income countries. To confirm and further explore preliminary data in Senegal, we aimed to determine 3 years after a first study the HIV-1 genetic diversity in three different viral regions. From 109 samples available in 2007, 93 were sequenced in gag, 77 in env, and 60 in pol. Phylogenetic analysis showed that subtype C predominated (38-52%), followed by CRF02_AG (30-40%), subtype B (13-17%), and CRF09_cpx (2.6-5%). Subsubtype A3 and strains tightly linked to CRF43_02G were identified in env and gag, respectively, and 12% of the samples were unique recombinants. Six transmission chains involving two to seven individuals were identified. Some strains carried resistance mutations inside transmission chains. This study confirmed the existence of a dual epidemic in Senegal and emphasized the need to strengthen prevention programs to avoid strains intermixing between low-risk women and high-risk men.
