%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Ndiaye, H. D.
%A Tchiakpe, E.
%A Vidal, Nicole
%A Ndiaye, O.
%A Diop, A. K.
%A Peeters, Martine
%A Mboup, S.
%A Toure-Kane, C.
%T HIV Type 1 subtype C remains the predominant subtype in men having sex with men in Senegal
%D 2013
%L fdi:010060566
%G ENG
%J Aids Research and Human Retroviruses
%@ 0889-2229
%K SENEGAL
%M ISI:000323372600014
%N 9
%P 1265-1272
%R 10.1089/aid.2013.0140
%U https://www.documentation.ird.fr/hor/fdi:010060566
%> https://www.documentation.ird.fr/intranet/publi/2013/09/010060566.pdf
%V 29
%W Horizon (IRD)
%X HIV-1 epidemics are expanding among men who have sex with men in low-and middle-income countries. To confirm and further explore preliminary data in Senegal, we aimed to determine 3 years after a first study the HIV-1 genetic diversity in three different viral regions. From 109 samples available in 2007, 93 were sequenced in gag, 77 in env, and 60 in pol. Phylogenetic analysis showed that subtype C predominated (38-52%), followed by CRF02_AG (30-40%), subtype B (13-17%), and CRF09_cpx (2.6-5%). Subsubtype A3 and strains tightly linked to CRF43_02G were identified in env and gag, respectively, and 12% of the samples were unique recombinants. Six transmission chains involving two to seven individuals were identified. Some strains carried resistance mutations inside transmission chains. This study confirmed the existence of a dual epidemic in Senegal and emphasized the need to strengthen prevention programs to avoid strains intermixing between low-risk women and high-risk men.
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