Publications des scientifiques de l'IRD

Chen S., Cai W. P., He J. Y., Vidal Nicole, Lai C. H., Guo W. Z., He H. L., Chen X. J., Fu L. S., Peeters Martine, Delaporte Eric, Andrieu J. M., Lu Louis. (2012). Molecular epidemiology of Human Immunodeficiency Virus Type 1 in Guangdong Province of Southern China. Plos One, 7 (11), p. e48747. ISSN 1932-6203.

Titre du document
Molecular epidemiology of Human Immunodeficiency Virus Type 1 in Guangdong Province of Southern China
Année de publication
2012
Type de document
Article référencé dans le Web of Science WOS:000311935800118
Auteurs
Chen S., Cai W. P., He J. Y., Vidal Nicole, Lai C. H., Guo W. Z., He H. L., Chen X. J., Fu L. S., Peeters Martine, Delaporte Eric, Andrieu J. M., Lu Louis
Source
Plos One, 2012, 7 (11), p. e48747 ISSN 1932-6203
Background: Although the outbreak of human immunodeficiency virus type 1 (HIV-1) in Guangdong has been documented for more than a decade, the molecular characteristics of such a regional HIV-1 epidemic remained unknown. Methodology/Principal Findings: By sequencing of HIV-1 pol/env genes and phylogenetic analysis, we performed a molecular epidemiologic study in a representative subset (n = 200) of the 508 HIV-1-seropositive individuals followed up at the center for HIV/AIDS care and treatment of Guangzhou Hospital of Infectious Diseases. Of 157 samples (54.1% heterosexual acquired adults, 20.4% needle-sharing drug users, 5.7% receivers of blood transfusion, 1.3% men who have sex with men, and 18.5% remained unknown) with successful sequencing for both pol and env genes, 105 (66.9%) HIV-1 subtype CRF01_AE and 24 (15.3%) CRF07_BC, 9 (5.7%) B', 5 (3.2%) CRF08_BC, 5 (3.2%) B, 1 (0.6%) C, 3 (1.9%) CRF02_AG, and 5 (3.2%) inter-region recombinants were identified within pol/env sequences. Thirteen (8.3%) samples (3 naives, 6 and 5 received with antiretroviral treatment [ART] 1-21 weeks and >= 24 weeks respectively) showed mutations conferring resistance to nucleoside/nonnucleoside reverse transcriptase inhibitors or protease inhibitors. Among 63 ART-naive patients, 3 (4.8%) showed single or multiple drug resistant mutations. Phylogenetic analysis showed 8 small clusters (2-3 sequences/cluster) with only 17 (10.8%) sequences involved. Conclusion/Significance: This study confirms that sexual transmission with dominant CRF01_AE strain is a major risk for current HIV-1 outbreak in the Guangdong's general population. The transmission with drug-resistant variants is starting to emerge in this region.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020] ; Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
CHINE ; GUANGDONG PROVINCE
Localisation
Fonds IRD [F B010058830]
Identifiant IRD
fdi:010058830
Contact