%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Chen, S.
%A Cai, W. P.
%A He, J. Y.
%A Vidal, Nicole
%A Lai, C. H.
%A Guo, W. Z.
%A He, H. L.
%A Chen, X. J.
%A Fu, L. S.
%A Peeters, Martine
%A Delaporte, Eric
%A Andrieu, J. M.
%A Lu, Louis
%T Molecular epidemiology of Human Immunodeficiency Virus Type 1 in Guangdong Province of Southern China
%D 2012
%L fdi:010058830
%G ENG
%J Plos One
%@ 1932-6203
%K CHINE ; GUANGDONG PROVINCE
%M ISI:000311935800118
%N 11
%P e48747
%R 10.1371/journal.pone.0048747
%U https://www.documentation.ird.fr/hor/fdi:010058830
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-09/010058830.pdf
%V 7
%W Horizon (IRD)
%X Background: Although the outbreak of human immunodeficiency virus type 1 (HIV-1) in Guangdong has been documented for more than a decade, the molecular characteristics of such a regional HIV-1 epidemic remained unknown. Methodology/Principal Findings: By sequencing of HIV-1 pol/env genes and phylogenetic analysis, we performed a molecular epidemiologic study in a representative subset (n = 200) of the 508 HIV-1-seropositive individuals followed up at the center for HIV/AIDS care and treatment of Guangzhou Hospital of Infectious Diseases. Of 157 samples (54.1% heterosexual acquired adults, 20.4% needle-sharing drug users, 5.7% receivers of blood transfusion, 1.3% men who have sex with men, and 18.5% remained unknown) with successful sequencing for both pol and env genes, 105 (66.9%) HIV-1 subtype CRF01_AE and 24 (15.3%) CRF07_BC, 9 (5.7%) B', 5 (3.2%) CRF08_BC, 5 (3.2%) B, 1 (0.6%) C, 3 (1.9%) CRF02_AG, and 5 (3.2%) inter-region recombinants were identified within pol/env sequences. Thirteen (8.3%) samples (3 naives, 6 and 5 received with antiretroviral treatment [ART] 1-21 weeks and >= 24 weeks respectively) showed mutations conferring resistance to nucleoside/nonnucleoside reverse transcriptase inhibitors or protease inhibitors. Among 63 ART-naive patients, 3 (4.8%) showed single or multiple drug resistant mutations. Phylogenetic analysis showed 8 small clusters (2-3 sequences/cluster) with only 17 (10.8%) sequences involved. Conclusion/Significance: This study confirms that sexual transmission with dominant CRF01_AE strain is a major risk for current HIV-1 outbreak in the Guangdong's general population. The transmission with drug-resistant variants is starting to emerge in this region.
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