@article{fdi:010058830,
  title = {{M}olecular epidemiology of {H}uman {I}mmunodeficiency {V}irus {T}ype 1 in {G}uangdong {P}rovince of {S}outhern {C}hina},
  author = {{C}hen, {S}. and {C}ai, {W}. {P}. and {H}e, {J}. {Y}. and {V}idal, {N}icole and {L}ai, {C}. {H}. and {G}uo, {W}. {Z}. and {H}e, {H}. {L}. and {C}hen, {X}. {J}. and {F}u, {L}. {S}. and {P}eeters, {M}artine and {D}elaporte, {E}ric and {A}ndrieu, {J}. {M}. and {L}u, {L}ouis},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {A}lthough the outbreak of human immunodeficiency virus type 1 ({HIV}-1) in {G}uangdong has been documented for more than a decade, the molecular characteristics of such a regional {HIV}-1 epidemic remained unknown. {M}ethodology/{P}rincipal {F}indings: {B}y sequencing of {HIV}-1 pol/env genes and phylogenetic analysis, we performed a molecular epidemiologic study in a representative subset (n = 200) of the 508 {HIV}-1-seropositive individuals followed up at the center for {HIV}/{AIDS} care and treatment of {G}uangzhou {H}ospital of {I}nfectious {D}iseases. {O}f 157 samples (54.1% heterosexual acquired adults, 20.4% needle-sharing drug users, 5.7% receivers of blood transfusion, 1.3% men who have sex with men, and 18.5% remained unknown) with successful sequencing for both pol and env genes, 105 (66.9%) {HIV}-1 subtype {CRF}01_{AE} and 24 (15.3%) {CRF}07_{BC}, 9 (5.7%) {B}', 5 (3.2%) {CRF}08_{BC}, 5 (3.2%) {B}, 1 (0.6%) {C}, 3 (1.9%) {CRF}02_{AG}, and 5 (3.2%) inter-region recombinants were identified within pol/env sequences. {T}hirteen (8.3%) samples (3 naives, 6 and 5 received with antiretroviral treatment [{ART}] 1-21 weeks and >= 24 weeks respectively) showed mutations conferring resistance to nucleoside/nonnucleoside reverse transcriptase inhibitors or protease inhibitors. {A}mong 63 {ART}-naive patients, 3 (4.8%) showed single or multiple drug resistant mutations. {P}hylogenetic analysis showed 8 small clusters (2-3 sequences/cluster) with only 17 (10.8%) sequences involved. {C}onclusion/{S}ignificance: {T}his study confirms that sexual transmission with dominant {CRF}01_{AE} strain is a major risk for current {HIV}-1 outbreak in the {G}uangdong's general population. {T}he transmission with drug-resistant variants is starting to emerge in this region.},
  keywords = {{CHINE} ; {GUANGDONG} {PROVINCE}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {7},
  numero = {11},
  pages = {e48747},
  ISSN = {1932-6203},
  year = {2012},
  DOI = {10.1371/journal.pone.0048747},
  URL = {https://www.documentation.ird.fr/hor/fdi:010058830},
}